Wong T S, Booth F W
Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225.
J Appl Physiol (1985). 1988 Aug;65(2):950-4. doi: 10.1152/jappl.1988.65.2.950.
A rat model of weight lifting that produces skeletal muscle enlargement utilizing regimens of resistance training similar to those employed in human training programs is described. The model consists of electrically stimulating the lower leg muscles to contract against a weighted pulley bar. Animals were subjected to training protocols employing low-frequency repetitions with high training loads within a training session. Initial maximum loads of between 200 and 800 g were progressively increased during the 16 wk of training. Work done at the end of the training period increased to an average value 66% higher than that performed at the start of training. The gastrocnemius wet weight and protein content increased (P less than 0.001) by 18 and 17%, respectively, in the stimulated loaded leg in all but one training protocol, a program in which rats were exercised more frequently. RNA content, but not concentration, was increased in the trained gastrocnemius muscle from each protocol, resulting in muscle enlargement. These data indicate that the basic model presented here provides a suitable vehicle for future studies into the biochemical events that may cause skeletal muscle enlargement during resistance training but, based on limited data, suggests that an increased frequency of training days may hinder muscle enlargement in this model.
本文描述了一种大鼠举重模型，该模型利用与人类训练计划中所采用的类似的阻力训练方案来使骨骼肌增大。该模型包括电刺激小腿肌肉以使其对抗加重的滑轮杆收缩。动物接受的训练方案是在一次训练中采用低频重复且训练负荷较高的方式。在为期16周的训练期间，初始最大负荷在200至800克之间逐步增加。训练期结束时所完成的功增加到比训练开始时所完成的功的平均值高66%。在除一种训练方案（即大鼠运动频率更高的方案）外的所有训练方案中，受刺激的负重腿的腓肠肌湿重和蛋白质含量分别增加了18%和17%（P<0.001）。来自每个训练方案的训练后的腓肠肌中RNA含量增加，但浓度未增加，从而导致肌肉增大。这些数据表明，本文所呈现的基本模型为未来研究阻力训练期间可能导致骨骼肌增大的生化事件提供了一个合适的载体，但基于有限的数据表明，增加训练天数的频率可能会阻碍该模型中的肌肉增大。
