Zhang Dongshan, Yang Ruhao, Wang Shixuan, Dong Zheng
Departments of Emergency Medicine and Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China ; Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, GA, USA.
Departments of Emergency Medicine and Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Drug Des Devel Ther. 2014 Feb 20;8:279-84. doi: 10.2147/DDDT.S56801. eCollection 2014.
Paclitaxel (Taxol), one of the most important anticancer drugs, has been used for therapy of different types of cancers. Mechanistically, paclitaxel arrests cell cycle and induces cell death by stabilizing microtubules and interfering with microtubule disassembly in cell division. Recently, it has been found that low-dose paclitaxel seems promising in treating non-cancer diseases, such as skin disorders, renal and hepatic fibrosis, inflammation, axon regeneration, limb salvage, and coronary artery restenosis. Future studies need to understand the mechanisms underlying these effects in order to design therapies with specificity.
紫杉醇（泰素）是最重要的抗癌药物之一，已被用于治疗不同类型的癌症。从机制上讲，紫杉醇通过稳定微管并干扰细胞分裂中的微管解聚来阻止细胞周期并诱导细胞死亡。最近，人们发现低剂量紫杉醇在治疗非癌症疾病方面似乎很有前景，如皮肤疾病、肾和肝纤维化、炎症、轴突再生、肢体保全以及冠状动脉再狭窄。未来的研究需要了解这些作用背后的机制，以便设计出具有特异性的治疗方法。
