Environ Sci Process Impacts. 2013 Jan;15(1):23-38. doi: 10.1039/c2em30237c.
The increased use of and interest in nanoparticles (NPs) have resulted in an enormous amount of NPs with different compositions and physico-chemical properties. These unique properties not only determine their utility for (bio-medical) applications, but also their toxicity. Recently, "nano-researchers" became aware of the importance of determining the characteristics since they might be predictors of their toxicity. Currently, we face a large set of (non-coordinated) experiments with miscellaneous objectives resulting in a large quantity of available (and often incomplete) data, which hamper the unraveling of the complex interrelated NP characteristics with experimental results. Here, we try to link different critical physico-chemical characteristics separately with toxicity observed in both in vitro and in vivo models.
纳米粒子（NPs）的使用和关注度不断增加，导致具有不同组成和物理化学特性的纳米粒子数量巨大。这些独特的性质不仅决定了它们在（生物医学）应用中的用途，也决定了它们的毒性。最近，“纳米研究人员”意识到确定这些特性的重要性，因为它们可能是毒性的预测指标。目前，我们面临着大量（非协调）实验，这些实验的目的各不相同，导致大量可用（且往往不完整）的数据，这阻碍了我们从实验结果中揭示复杂的相互关联的 NP 特性。在这里，我们试图分别将不同的关键物理化学特性与体外和体内模型中观察到的毒性联系起来。
