Microbiol Immunol. 2014 Mar;58(3):215-8. doi: 10.1111/1348-0421.12145.
To investigate systemic cytokine responses in human bocavirus (HBoV)-associated lower respiratory tract infection, serum cytokine profiles were analyzed in HBoV positive-children (n=14) using multiplex immunoassay. Concentrations of TNF-a, IL-2, IL-5 and IL-8 on admission were significantly different from those of respiratory syncytial virus-positive children (n=28). This unique cytokine response might partly explain some characteristic clinical features of HBoV-associated respiratory infection.
为了研究人类博卡病毒（HBoV）相关下呼吸道感染的全身细胞因子反应，采用多重免疫分析法分析了 HBoV 阳性患儿（n=14）的血清细胞因子谱。入院时 TNF-a、IL-2、IL-5 和 IL-8 的浓度与呼吸道合胞病毒阳性患儿（n=28）的浓度有显著差异。这种独特的细胞因子反应可能部分解释了 HBoV 相关呼吸道感染的一些特征性临床特征。
