人博卡病毒是台湾地区儿童呼吸道感染的重要病因。
Human bocavirus as an important cause of respiratory tract infection in Taiwanese children.
机构信息
Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
出版信息
J Microbiol Immunol Infect. 2011 Oct;44(5):323-7. doi: 10.1016/j.jmii.2011.01.036. Epub 2011 Jan 20.
BACKGROUND
Human bocavirus (HBoV), first described in September 2005, was considered a causative agent of previously unexplained respiratory tract diseases. However, only few reports provide the evidence for an association between HBoV and respiratory tract diseases. We conducted a prospective clinical and molecular study of HBoV in Taiwan.
METHODS
We enrolled 705 children who visited our outpatient pediatric clinics in a medical center because of symptoms and signs of respiratory tract infections from November 2008 to October 2009. Throat swab was performed and HBoV polymerase chain reaction and viral culture were done simultaneously.
RESULTS
Positive viral results were confirmed in 159 (22.6%) of the 705 children. HBoV was found in 35 samples and it was supposed to be as a single virus in 32 samples because viral isolation of these 32 samples did not identify other virus. The other three patients had coinfection with another virus. One child got HBoV reinfection 6 months after the first infection. Seventy-one percentage of these HBoV infections occurred between November and March. Of the 34 children with positive HBoV, 26 (76%) patients were younger than 5 years; their common symptoms were cough, rhinorrhea, and fever; the most common diagnoses were bronchitis (34%, 12/35) and sinusitis (31%, 11/35) followed by pharyngitis (29%, 10/35) and asthma exacerbation (26%, 9/35). Three of the 34 patients needed hospitalization.
CONCLUSION
HBoV is an emerging human parvovirus that may cause respiratory tract infection in young children. Diseases associated with HBoV may range from pharyngitis, sinusitis, acute otitis media to bronchitis, asthma, and even pneumonia.
背景
人类博卡病毒（HBoV）于 2005 年 9 月首次被描述，被认为是先前无法解释的呼吸道疾病的致病因子。然而，只有少数报道提供了 HBoV 与呼吸道疾病之间关联的证据。我们在台湾进行了一项针对 HBoV 的前瞻性临床和分子研究。
方法
我们招募了 2008 年 11 月至 2009 年 10 月因呼吸道感染症状和体征而到我们医疗中心门诊就诊的 705 名儿童。同时进行咽喉拭子采样和 HBoV 聚合酶链反应和病毒培养。
结果
在 705 名儿童中，有 159 名（22.6%）的病毒检测结果为阳性。在 35 份样本中发现了 HBoV，其中 32 份样本被认为是单一病毒，因为这些 32 份样本的病毒分离未鉴定出其他病毒。另外三个患者存在另一种病毒的合并感染。有 1 名儿童在第一次感染后 6 个月发生 HBoV 再感染。这些 HBoV 感染中有 71%发生在 11 月至 3 月之间。在 34 名 HBoV 阳性的儿童中，26 名（76%）患儿年龄小于 5 岁；他们的常见症状是咳嗽、流涕和发热；最常见的诊断是支气管炎（34%，12/35）和鼻窦炎（31%，11/35），其次是咽炎（29%，10/35）和哮喘恶化（26%，9/35）。34 名患儿中有 3 名需要住院治疗。
结论
HBoV 是一种新兴的人类细小病毒，可能导致幼儿呼吸道感染。与 HBoV 相关的疾病范围从咽炎、鼻窦炎、急性中耳炎到支气管炎、哮喘，甚至肺炎不等。
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