尼日利亚艾滋病毒感染者的癌症负担：尼日利亚艾滋病-癌症匹配研究的初步发现。
Cancer burden among HIV-positive persons in Nigeria: preliminary findings from the Nigerian AIDS-cancer match study.
机构信息
Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, USA.
出版信息
Infect Agent Cancer. 2014 Mar 5;9(1):1. doi: 10.1186/1750-9378-9-1.
BACKGROUND
Although Nigeria has a large HIV epidemic, the impact of HIV on cancer in Nigerians is unknown.
METHODS
We conducted a registry linkage study using a probabilistic matching algorithm among a cohort of HIV positive persons registered at health facilities where the Institute of Human Virology Nigeria (IHVN) provides HIV prevention and treatment services. Their data was linked to data from 2009 to 2012 in the Abuja Cancer Registry. Match compatible files with first name, last name, sex, date of birth and unique HIV cohort identification numbers were provided by each registry and used for the linkage analysis. We describe demographic characteristics of the HIV clients and compute Standardized Incidence Ratios (SIRs) to evaluate the association of various cancers with HIV infection.
RESULTS
Between 2005 and 2012, 17,826 persons living with HIV (PLWA) were registered at IHVN. Their median age (Interquartile range (IQR)) was 33 (27-40) years; 41% (7246/17826) were men and 59% (10580/17826) were women. From 2009 to 2012, 2,029 clients with invasive cancers were registered at the Abuja Cancer Registry. The median age (IQR) of the cancer clients was 45 (35-68) years. Among PLWA, 39 cancer cases were identified, 69% (27/39) were incident cancers and 31% (12/39) were prevalent cancers. The SIR (95% CI) for the AIDS Defining Cancers were 5.7 (4.1, 7.2) and 2.0 (0.4, 3.5), for Kaposi Sarcoma and Cervical Cancer respectively.
CONCLUSION
The risk of Kaposi Sarcoma but not Cervical Cancer or Non-Hodgkin's Lymphoma, was significantly increased among HIV positive persons, compared to the general population in Nigeria.
背景
尽管尼日利亚存在大规模的 HIV 流行，但 HIV 对尼日利亚人癌症的影响尚不清楚。
方法
我们使用概率匹配算法在一个在尼日利亚人类病毒学研究所（IHVN）提供 HIV 预防和治疗服务的医疗机构注册的 HIV 阳性者队列中进行了一项登记处关联研究。他们的数据与 2009 年至 2012 年阿布贾癌症登记处的数据进行了关联。每个登记处都提供了可与首字母、姓氏、性别、出生日期和唯一的 HIV 队列识别号码相匹配的文件，并用于关联分析。我们描述了 HIV 患者的人口统计学特征，并计算了标准化发病比（SIR）来评估各种癌症与 HIV 感染之间的关联。
结果
2005 年至 2012 年间，IHVN 登记了 17826 名艾滋病毒感染者（PLWA）。他们的中位年龄（四分位间距（IQR））为 33（27-40）岁；41%（7246/17826）为男性，59%（10580/17826）为女性。2009 年至 2012 年间，阿布贾癌症登记处登记了 2029 名患有侵袭性癌症的患者。癌症患者的中位年龄（IQR）为 45（35-68）岁。在 PLWA 中，发现了 39 例癌症病例，69%（27/39）为新发病例，31%（12/39）为现患病例。艾滋病定义癌症的 SIR（95%CI）为 5.7（4.1，7.2），卡波西肉瘤和宫颈癌分别为 2.0（0.4，3.5）。
结论
与尼日利亚一般人群相比，HIV 阳性者患卡波西肉瘤的风险显著增加，但宫颈癌或非霍奇金淋巴瘤的风险则没有显著增加。
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