Lee J P, Lee S T
Department of Surgery, Chang Gung Medical College and Memorial Hospital, Taipei, Republic of China.
Surg Neurol. 1988 Oct;30(4):316-20. doi: 10.1016/0090-3019(88)90306-0.
The authors describe two cases of hepatocellular carcinoma presenting with the initial manifestations of an intracranial mass lesion without any symptoms or signs suggestive of the primary hepatic site of the tumor. The only clue of hepatic dysfunction was mild elevation of the SGOT and SGPT. The diagnosis could not be made until operation. It is unusual for the initial clinical presentation to be related to intracranial metastasis without evidence of hepatic involvement. Measurement of the serum alpha-fetoprotein and liver ultrasound examination are the most helpful screening tools for diagnosing hepatocellular carcinoma. The literature of hepatoma with cranial metastasis is reviewed.
作者描述了两例肝细胞癌，其最初表现为颅内肿块病变，而无任何提示肿瘤原发肝部位的症状或体征。肝功能障碍的唯一线索是谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）轻度升高。直到手术时才得以确诊。在没有肝脏受累证据的情况下，最初临床表现与颅内转移相关的情况并不常见。血清甲胎蛋白测定和肝脏超声检查是诊断肝细胞癌最有用的筛查工具。本文对肝癌伴颅内转移的文献进行了综述。
