癌症的产前起源。
The prenatal origins of cancer.
机构信息
Kids Cancer Centre, Sydney Children's Hospital, Randwick 2031, New South Wales, Australia; and the Children's Cancer Institute Australia for Medical Research, Lowy Cancer Centre, University of New South Wales, Randwick 2031, Australia.
Children's Cancer Institute Australia for Medical Research, Lowy Cancer Centre, University of New South Wales, Randwick 2031, Australia.
出版信息
Nat Rev Cancer. 2014 Apr;14(4):277-89. doi: 10.1038/nrc3679. Epub 2014 Mar 6.
Abstract
The concept that some childhood malignancies arise from postnatally persistent embryonal cells has a long history. Recent research has strengthened the links between driver mutations and embryonal and early postnatal development. This evidence, coupled with much greater detail on the cell of origin and the initial steps in embryonal cancer initiation, has identified important therapeutic targets and provided renewed interest in strategies for the early detection and prevention of childhood cancer.
摘要
某些儿童恶性肿瘤起源于出生后持续存在的胚胎细胞这一概念由来已久。最近的研究加强了驱动突变与胚胎和出生后早期发育之间的联系。这一证据，加上对起源细胞和胚胎癌起始初始步骤的更详细了解，确定了重要的治疗靶点，并为儿童癌症的早期检测和预防策略提供了新的关注。
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