Unit of Health-Care Epidemiology, Department of Public Health, University of Oxford, Oxford, OX3 7LF, United Kingdom.
Int J Eat Disord. 2014 Jul;47(5):507-15. doi: 10.1002/eat.22249. Epub 2014 Mar 5.
To calculate mortality of people with eating disorders (ED) in England, relative to that of people of the same age and sex, between 2001 and 2009. We were specifically interested in mortality amongst adolescents and young adults (15-24 years), and older adults (25-44 years).
We analyzed a NHS Hospital Episode Statistics (HES) dataset for all England, linked to death registrations, to calculate age- and sex-specific discharge rates for people with a diagnosis of ED and their subsequent mortality by one year after discharge.
The standardized mortality ratio (SMR) for adolescents and young adults with a diagnosis of ED was 7.8 (95% confidence interval: 4.4-11.2). This compares with an SMR for people of the same age with schizophrenia of 10.2 (8.3-12.2), with bipolar disorder of 3.6 (1.1-6.1, and with depression of 4.5 (3.6-5.3). Of the ED, the SMR for anorexia nervosa (AN) in people aged 15-24 was 11.5 (6.0-17.0), for bulimia nervosa (BN) was 4.1 (0-8.7), and eating disorders not otherwise specified (ED NOS) was 1.4 (0-4.0). For older adults aged 25-44 years, the SMR for ED was 10.7 (7.7-13.6). Specifically, for AN was 14.0 (9.2-18.8), for BN was 7.7 (3.5-11.9), and ED NOS was 4.7 (1.4-8.0), for schizophrenia was 7.3 (6.6-7.9), for bipolar disorder was 4.3 (3.5-5.1) and for depression was 4.9 (4.6-5.3). No deaths were recorded below 15 years of age.
This study confirms the high SMR associated with ED, notably with anorexia and bulimia.
计算 2001 年至 2009 年期间，英格兰进食障碍（ED）患者的死亡率与同年龄和性别的人群相比的相对死亡率。我们特别关注青少年和年轻人（15-24 岁）以及年龄较大的成年人（25-44 岁）的死亡率。
我们分析了英国国民保健系统（NHS）医院病例统计（HES）数据集，该数据集与死亡登记相关联，以计算出 ED 诊断患者的年龄和性别特定出院率，并在出院后一年计算其死亡率。
诊断为 ED 的青少年和年轻人的标准化死亡率比（SMR）为 7.8（95%置信区间：4.4-11.2）。这与同年龄段精神分裂症患者的 SMR（10.2）、双相情感障碍患者的 SMR（3.6）和抑郁症患者的 SMR（4.5）相比。在 ED 中，15-24 岁 AN 的 SMR 为 11.5（6.0-17.0），BN 的 SMR 为 4.1（0-8.7），未特定说明的 ED 的 SMR 为 1.4（0-4.0）。对于 25-44 岁的年龄较大的成年人，ED 的 SMR 为 10.7（7.7-13.6）。具体而言，AN 的 SMR 为 14.0（9.2-18.8），BN 的 SMR 为 7.7（3.5-11.9），EDNOS 的 SMR 为 4.7（1.4-8.0），精神分裂症的 SMR 为 7.3（6.6-7.9），双相情感障碍的 SMR 为 4.3（3.5-5.1），抑郁症的 SMR 为 4.9（4.6-5.3）。未记录到 15 岁以下的死亡人数。
本研究证实了与 ED 相关的高 SMR，尤其是与厌食症和贪食症相关。
