Camphausen R T, Jones R L, Brennan P J
Department of Microbiology, Colorado State University, Fort Collins 80523.
Am J Vet Res. 1988 Aug;49(8):1307-10.
Four prototype strains of Mycobacterium paratuberculosis contained the type-specific glycopeptidolipid antigen of serovar 8 of the M avium complex. This glycolipid was distinguished by a 4,6-(1'-carboxyethylidene)-3-O-methyl-beta-D-glucopyranosyl terminal unit. Of 59 low-passage, field isolates of M paratuberculosis, 2 contained this antigen, and these 2 isolates were indistinguishable from M avium serovar 8. However, most M paratuberculosis isolates had no characteristic surface glycopeptidolipid. Seemingly, M paratuberculosis, long regarded as a single species and the causative agent of bovine paratuberculosis, is not a homogeneous taxon. Most isolates obtained from infected ruminants may be antigenically defective, variants of M avium and, thereby, more successful pathogens.
四株副结核分枝杆菌原型菌株含有鸟分枝杆菌复合群血清型8的型特异性糖肽脂抗原。这种糖脂的特征是具有一个4,6-(1'-羧基亚乙基)-3-O-甲基-β-D-吡喃葡萄糖基末端单元。在59株低传代的副结核分枝杆菌野外分离株中，有2株含有这种抗原，并且这2株分离株与鸟分枝杆菌血清型8无法区分。然而，大多数副结核分枝杆菌分离株没有特征性的表面糖肽脂。看来，长期以来被视为单一物种且是牛副结核病病原体的副结核分枝杆菌并非一个同质的分类单元。从受感染反刍动物中获得的大多数分离株可能在抗原性上有缺陷，是鸟分枝杆菌的变体，因此是更成功的病原体。
