血小板参数和血液学指标在心肌梗死和不稳定型心绞痛中的作用。

Role of platelet parameters and haematological indices in myocardial infarction and unstable angina.

作者信息

Yaghoubi Alireza, Golmohamadi Zahra, Alizadehasl Azin, Azarfarin Rasoul

机构信息

Cardiovascular Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

J Pak Med Assoc. 2013 Sep;63(9):1133-7.

PMID:24601192

Abstract

OBJECTIVE

To explore the significance of platelet parameters, including mean platelet volume, platelet count and other haematological indices, in patients of acute coronary syndrome.

METHODS

In this one-year retrospective cross-sectional study in 2010, a total of 631 patients were enrolled at the Cardiovascular Research Institute, Tabriz University of Medical Sciences, Iran, and classified into three groups: myocardial infarction, unstable angina, and Control. Cardiovascular risk factors such as smoking, diabetes mellitus, hyperlipidaemia and hypertension status were compared. Blood samples were collected for the measurement of platelet count, mean platelet volume and other haematological indices, including prothrombin time, partial thromoplastin time, blood group and Rh, haematocrit, haemoglobin, and erythrocyte sedimentation rate. SPSS 18 was used for statistical analysis.

RESULTS

Of the total, there were 210 (33.3%; 163 men, 47 women) with myocardial infarction whose mean age was 62.7 +/- 14.2 years; 211 (33.3%; 110 men, 101 women) had unstable angina with a mean age of 63.5 +/- 3.1 years and 210 (33.3%; 117 men, 90 women) health controls with a mean age of 60.6 +/- 12.8 years. The mean platelet volume values of patients in the first two groups were significantly higher than the control group (10.14 +/- 1.05 fL, 9.82 +/- 0.93 fL and 9.34 +/- 1.14 fL, respectively; p < 0.001). The platelet count was detected to be significantly lower in the patients than the controls (207.92 +/- 58.40 x 109/L, 220.18 +/- 65.81 x 109/L, 23 +/- 56.10x109/L, respectively, p < 0.001). While blood cell count was significantly higher in those with myocardial infarction compared to the unstable angina patients and control group ( P < 0.001). Differences in mean values of mean platelet volume between the two patient groups was not significant, but mean values of platelet count was statistically significant between these two groups ( p < 0.04).

CONCLUSION

Mean platelet volume and platelet count may be considered prognostic markers for acute coronary syndrome.

摘要

目的

探讨血小板参数，包括平均血小板体积、血小板计数及其他血液学指标在急性冠脉综合征患者中的意义。

方法

在这项于2010年开展的为期一年的回顾性横断面研究中，伊朗大不里士医科大学心血管研究所共纳入631例患者，分为三组：心肌梗死组、不稳定型心绞痛组和对照组。比较吸烟、糖尿病、高脂血症和高血压状态等心血管危险因素。采集血样以测定血小板计数、平均血小板体积及其他血液学指标，包括凝血酶原时间、活化部分凝血活酶时间、血型及Rh、血细胞比容、血红蛋白和红细胞沉降率。使用SPSS 18进行统计分析。

结果

总计有210例（33.3%；男性163例，女性47例）心肌梗死患者，平均年龄为62.7±14.2岁；211例（33.3%；男性110例，女性101例）不稳定型心绞痛患者，平均年龄为63.5±3.1岁；210例（33.3%；男性117例，女性90例）健康对照者，平均年龄为60.6±12.8岁。前两组患者的平均血小板体积值显著高于对照组（分别为10.14±1.05 fL、9.82±0.93 fL和9.34±1.14 fL；p<0.001）。检测发现患者的血小板计数显著低于对照组（分别为207.92±58.40×10⁹/L、220.18±65.81×10⁹/L、23±56.10×10⁹/L，p<0.001）。与不稳定型心绞痛患者和对照组相比，心肌梗死患者的血细胞计数显著更高（P<0.001）。两组患者平均血小板体积的均值差异不显著，但两组间血小板计数的均值差异具有统计学意义（p<0.04）。