埃塞俄比亚西北部贡德尔大学医院高血压和血压正常个体的一些血液学参数的比较横断面研究。
A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia.
作者信息
Enawgaw Bamlaku, Adane Nigist, Terefe Betelihem, Asrie Fikir, Melku Mulugeta
机构信息
Department of Hematology & Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
BMC Hematol. 2017 Nov 28;17:21. doi: 10.1186/s12878-017-0093-9. eCollection 2017.
BACKGROUND
Hypertension is a major health problem worldwide. It can lead to cardiovascular disease and also leads to functional disturbances including hematological parameters. The abnormalities of haematological parameters may enhance an end-organ damage. Therefore, the aim of this study was to assess some hematological parameters of hypertensive individuals in comparison with normotensive individuals at University of Gondar hospital, northwest Ethiopia.
METHODS
A cross sectional comparative study was conducted from October to November 2015 on a total of 126 hypertensive and 126 normotensive individuals at University of Gondar Hospital. All participants after taking informed consent were interviewed for detailed history and 3 ml of blood was collected for hematological test analysis. Independent -test and the Mann Whitney -test were used to find out significant difference and Pearson's and Spearman's correlation were used for correlation test. values less than 0.05 was considered the level of significance.
RESULT
From a total of 252 study subjects, about 67.5% were females. The mean age of study subjects was 50.3 ± 11 years for hypertensive individuals and 49.8 ± 11.6 years for normotensive individuals with range of 18-65 years. In the present study, the median (IQR) value of WBC, RBC, Hgb, HCT, MCV and the mean value of MCHC, RDW, MPV and PDW were significantly higher in hypertensive group compared to apparently healthy normotensive groups. Additionally, WBC, RBC, Hgb, HCT and PLT showed statistically significant positive correlations with blood pressure indices. Platelet count and MCH did not show statistically significant difference between the two groups.
CONCLUSION
Hypertension has impact on hematological parameters. In this study, the mean and median values of haematological parameters in hypertensive individuals were significantly different compared to apparently healthy normotensive individuals. Hence, hematological parameters can be used to monitor the prognosis of the disease and manage hypertensive related complications, and it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated hematological disorders.
背景
高血压是全球主要的健康问题。它可导致心血管疾病，还会引发包括血液学参数在内的功能紊乱。血液学参数异常可能会加重靶器官损害。因此，本研究旨在评估埃塞俄比亚西北部贡德尔大学医院高血压患者与血压正常者的一些血液学参数。
方法
2015年10月至11月，在贡德尔大学医院对126例高血压患者和126例血压正常者进行了一项横断面比较研究。所有参与者在签署知情同意书后，接受详细病史访谈，并采集3毫升血液进行血液学检测分析。采用独立样本t检验和曼-惠特尼U检验来找出显著差异，使用皮尔逊相关系数和斯皮尔曼相关系数进行相关性检验。P值小于0.05被视为具有统计学意义。
结果
在总共252名研究对象中，约67.5%为女性。高血压患者的研究对象平均年龄为50.3±11岁，血压正常者为49.8±11.6岁，年龄范围为18 - 65岁。在本研究中，与明显健康的血压正常组相比，高血压组白细胞、红细胞、血红蛋白、血细胞比容、平均红细胞体积的中位数（四分位间距）值以及平均红细胞血红蛋白浓度、红细胞分布宽度、平均血小板体积和血小板分布宽度的平均值显著更高。此外，白细胞、红细胞、血红蛋白、血细胞比容和血小板计数与血压指标呈统计学显著正相关。两组之间血小板计数和平均红细胞血红蛋白含量无统计学显著差异。
结论
高血压对血液学参数有影响。在本研究中，高血压患者血液学参数的平均值和中位数与明显健康的血压正常者相比有显著差异。因此，血液学参数可用于监测疾病预后和管理高血压相关并发症，对高血压患者评估血液学参数很重要，这可能有助于预防与血液系统疾病相关的并发症。
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