4-硝基吡唑的区域选择性和导向C-H活化
Regioselective and guided C-H activation of 4-nitropyrazoles.
作者信息
Iaroshenko Viktor O, Gevorgyan Ashot, Davydova Olena, Villinger Alexander, Langer Peter
机构信息
Institut für Chemie, Universität Rostock , Albert-Einstein-Str. 3a, 18059 Rostock, Germany.
出版信息
J Org Chem. 2014 Apr 4;79(7):2906-15. doi: 10.1021/jo4025418. Epub 2014 Mar 24.
PMID:24601649
Abstract
A divergent and regioselective approach to 5-aryl-4-nitro-1H-pyrazoles was developed by guided transition-metal-catalyzed arylation of 4-nitro-1H-pyrazoles. This method provides a convenient tool for the functionalization of the pharmacologically relevant pyrazole scaffold. The scope and limitations of the methodology were studied.
摘要
通过导向的过渡金属催化4-硝基-1H-吡唑的芳基化反应，开发了一种合成5-芳基-4-硝基-1H-吡唑的发散性区域选择性方法。该方法为药理学相关吡唑骨架的官能化提供了一种便捷工具。研究了该方法的适用范围和局限性。
Zotero 插件