St. Olaf College , 1520 St. Olaf Avenue, Northfield, Minnesota 55057, United States.
J Org Chem. 2017 Jul 7;82(13):6946-6957. doi: 10.1021/acs.joc.7b00550. Epub 2017 Jun 15.
Pd-catalyzed arylation or benzylation of nitroazoles using aryl sulfonates or benzyl acetates is described. Electronically varied aryl tosylates and mesylates, as well as benzyl acetates, afford the arylated and benzylated products. Arylation of nitrobenzene is also reported. The relative rate for the arylation of halides is greater than that of tosylates using the reported reaction parameters. These studies enhance the scope of electrophiles for nitroarene arylations and benzylations, which was hitherto limited to the use of halide electrophiles.
本文描述了使用芳基磺酸盐或苄基醋酸盐的 Pd 催化的硝基唑的芳基化或苄基化反应。电子变化的芳基对甲苯磺酸盐和甲磺酸盐以及苄基醋酸盐提供了芳基化和苄基化产物。还报道了硝基苯的芳基化。在报道的反应条件下，卤化物的芳基化相对速率大于对甲苯磺酸盐的芳基化相对速率。这些研究扩展了用于硝基芳烃芳基化和苄基化的亲电试剂的范围，此前仅限于使用卤代亲电试剂。
