Limmathurotsakul D, Paeyao A, Wongratanacheewin S, Saiprom N, Takpho N, Thaipadungpanit J, Chantratita N, Wuthiekanun V, Day N P J, Peacock S J
Department of Tropical Hygiene, Mahidol University, Bangkok, Thailand; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Clin Microbiol Infect. 2014 Nov;20(11):O854-6. doi: 10.1111/1469-0691.12614. Epub 2014 Mar 29.
We examined whether quantitative biofilm formation and/or lipopolysaccharide type of Burkholderia pseudomallei was associated with relapsing melioidosis. We devised a 1:4 nested case-control study in which both cases and controls were drawn from a cohort of patients with primary melioidosis. Paired isolates from 80 patients with relapse and single isolates from 184 patients without relapse were tested. Relapse was associated with biofilm formation of the primary infecting isolate (conditional OR 2.03; 95% CI 1.27-3.25; p 0.003), but not with lipopolysaccharide type (p 0.74). This finding highlights the importance of biofilm formation in relapsing melioidosis.
我们研究了类鼻疽伯克霍尔德菌的定量生物膜形成和/或脂多糖类型是否与类鼻疽复发相关。我们设计了一项1:4巢式病例对照研究，病例和对照均来自原发性类鼻疽患者队列。对80例复发患者的配对分离株和184例未复发患者的单株分离株进行了检测。复发与原发性感染分离株的生物膜形成有关（条件性比值比2.03；95%可信区间1.27 - 3.25；p = 0.003），但与脂多糖类型无关（p = 0.74）。这一发现凸显了生物膜形成在类鼻疽复发中的重要性。
