Matusiak Łukasz, Bieniek Andrzej, Szepietowski Jacek C
Department of Dermatology, Venereology and Allergology, Medical University Chałubińskiego 1,, 50-368 Wrocław, Poland.
Acta Derm Venereol. 2014 Nov;94(6):699-702. doi: 10.2340/00015555-1841.
The bacterial superinfection in hidradenitis suppurativa (HS), although it does not initiate the disease itself, seems to be one of the major contributors to an inflammatory vicious circle. Antibiotic therapy is therefore commonly prescribed in HS. This study was undertaken to evaluate the prescription of systemic antibiotics in the light of bacteriological cultures and antibiograms. The study was conducted on a group of 69 patients with HS. The huge majority (n=62) of the patients were treated with antibiotics. The antibiotics were prescribed 132 times and taken for a mean period of 9.9 ± 8.9 weeks. The most commonly used antibiotic was doxycycline (16.7%). The majority of the patients had a polymicrobial flora with up to 5 species, predominantly staphylococci and bacteria of intestinal flora. The highest effectiveness against isolates was observed for carbapanems, penicillins with β-lactamase inhibitors and fluoroquinolones - 8.5%, 11.9%, and 11.9% of resistant strains, respectively. In daily practice penicillins with β-lactamase inhibitors or fluoroquinolones could serve as first-line therapy of HS.
化脓性汗腺炎（HS）中的细菌重叠感染虽然并非引发该病的病因，但似乎是导致炎症恶性循环的主要因素之一。因此，HS患者通常会接受抗生素治疗。本研究旨在根据细菌培养和药敏试验结果评估全身性抗生素的处方情况。该研究针对一组69例HS患者开展。绝大多数（n = 62）患者接受了抗生素治疗。抗生素共开具了132次，平均服用时间为9.9±8.9周。最常用的抗生素是多西环素（16.7%）。大多数患者的菌群为多种微生物，多达5种，主要是葡萄球菌和肠道菌群细菌。对分离菌有效性最高的是碳青霉烯类、含β-内酰胺酶抑制剂的青霉素类和氟喹诺酮类——耐药菌株分别占8.5%、11.9%和11.9%。在日常实践中，含β-内酰胺酶抑制剂的青霉素类或氟喹诺酮类可作为HS的一线治疗药物。
