Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany; European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.
Laboratory of Clinical Microbiology, Necker-Enfants Malades Hospital, Assistance publique - Hôpitaux de Paris, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Inserm U1151, équipe 11 "Physiopathologie des infections systémiques", Paris, France; Centre d'Infectiologie Necker-Pasteur, Paris, France.
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S12-8. doi: 10.1016/j.jaad.2015.07.041.
Given that follicular papules and pustules, as well as nodules and abscesses, are the clinical hallmarks of hidradenitis suppurativa (HS), an infectious, bacterial pathway has been suspected in the pathogenesis of this chronic, inflammatory condition. Elucidating the behavior and role of bacterial species in HS and their interaction with cutaneous innate immunity will provide more insight into the pathophysiology of this condition. This review of prospective investigations suggests a synergistic relationship between impaired innate immunity and microbial factors in the etiology of HS.
鉴于滤泡性丘疹和脓疱以及结节和脓肿是化脓性汗腺炎（HS）的临床特征，因此人们怀疑这种慢性炎症性疾病的发病机制与感染性细菌途径有关。阐明 HS 中细菌种类的行为和作用及其与皮肤固有免疫的相互作用将为该疾病的病理生理学提供更多的深入了解。对前瞻性研究的综述表明，固有免疫受损和微生物因素在 HS 的病因学中存在协同关系。
