Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada.
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S42-6. doi: 10.1016/j.jaad.2015.07.049.
Traditional systemic therapies are frequently prescribed for the treatment of hidradenitis suppurativa (HS). Clinicians consider antibiotics, retinoids, antiandrogens, immunosuppressants, and less common treatment, such as fumarates, in the management of HS. Different classes of medications have been selected to treat HS based on their ability to target various pathways of the condition. Concerns about infection, such as infection with Clostridium difficile, necessitates switching therapy or shortening the course of therapy with specific antibiotics. This review explores the outcomes with the use of numerous medical therapies and postulates explanations for their efficacy or lack of response. Data on long-term safety and efficacy with traditional systemic therapies are lacking.
传统的全身性治疗经常被用于治疗化脓性汗腺炎（HS）。临床医生会考虑抗生素、类视黄醇、抗雄激素、免疫抑制剂以及较少见的治疗方法，如富马酸盐，来管理 HS。根据其靶向疾病各种途径的能力，选择不同类别的药物来治疗 HS。由于存在感染（如艰难梭菌感染）的担忧，需要切换治疗或缩短特定抗生素的疗程。本综述探讨了使用多种药物治疗的结果，并对其疗效或无反应的原因进行了推测。缺乏传统全身性治疗的长期安全性和疗效数据。
