医学：对抗进化以对抗疾病。
Medicine. Combating evolution to fight disease.
机构信息
Departments of Molecular and Human Genetics, Biochemistry and Molecular Biology, Molecular Virology and Microbiology, and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Science. 2014 Mar 7;343(6175):1088-9. doi: 10.1126/science.1247472.
Abstract
Molecular mechanisms that generate biological diversity are rewriting ideas about how evolution proceeds, with implications for treating disease.
摘要
产生生物多样性的分子机制正在改写关于进化如何进行的观念，这对疾病治疗具有重要意义。
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本文引用的文献
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Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.紧密协调的蛋白质翻译和 HSF1 激活支持合成代谢恶性状态。
Science. 2013 Jul 19;341(6143):1238303. doi: 10.1126/science.1238303.
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The fungal Achilles' heel: targeting Hsp90 to cripple fungal pathogens.真菌的致命弱点：靶向 Hsp90 以削弱真菌病原体。
Curr Opin Microbiol. 2013 Aug;16(4):377-84. doi: 10.1016/j.mib.2013.03.005. Epub 2013 Apr 13.
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β-Lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity.β-内酰胺类抗生素通过降低复制保真度，经 RpoS 介导促进细菌突变。
Nat Commun. 2013;4:1610. doi: 10.1038/ncomms2607.
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APOBEC3B is an enzymatic source of mutation in breast cancer.APOBEC3B 是乳腺癌突变的酶源。
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