Lindor Noralane M, Win Aung Ko, Gallinger Steven, Daftary Darshana, Thibodeau Stephen N, Silva Renato, Letra Ariadne
Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Blvd,, Scottsdale, AZ 85259, USA.
Hered Cancer Clin Pract. 2014 Mar 10;12(1):7. doi: 10.1186/1897-4287-12-7.
Germline mutations in APC and AXIN2 are both associated with colon neoplasia as well as anomalous dental development. We tested the hypothesis that congenitally missing teeth may occur more commonly in individuals diagnosed with colorectal cancer than in individuals without this diagnosis.
Via a survey conducted on 1636 individuals with colorectal cancer (CRC) and 2788 individuals with no colorectal cancer from the Colon Cancer Family Registry, self-reported information on congenitally missing teeth was collected. The frequency of missing teeth between cases and controls was compared using Pearson's chi-squared test or Fisher's exact test.
4.8% of cases and 5.7% of controls reported having at least one missing tooth (p = 0.20). When we stratified by recruitment site, gender, and mutation status where available, frequency of missing teeth was not statistically significantly different between cases and controls.
This study did not provide support for there being a general predisposition to missing teeth among a large cohort of CRC patients. The study neither addresses nor excludes the possibility, however, that individuals presenting with notable hypodontia/oligodontia might still have an increased risk for colorectal neoplasia.
APC和AXIN2的胚系突变均与结肠肿瘤形成以及牙齿发育异常有关。我们检验了这样一个假设，即与未被诊断为结直肠癌的个体相比，被诊断为结直肠癌的个体先天性缺牙可能更常见。
通过对来自结肠癌家族登记处的1636例结直肠癌患者和2788例非结直肠癌患者进行调查，收集了关于先天性缺牙的自我报告信息。使用Pearson卡方检验或Fisher精确检验比较病例组和对照组之间缺牙的频率。
4.8%的病例和5.7%的对照报告至少有一颗牙齿缺失（p = 0.20）。当我们按招募地点、性别和可用的突变状态进行分层时，病例组和对照组之间的缺牙频率没有统计学显著差异。
本研究没有为一大群结直肠癌患者普遍存在缺牙倾向提供支持。然而，该研究既未涉及也未排除这样一种可能性，即表现出明显少牙症/无牙症的个体结直肠肿瘤形成的风险可能仍然增加。
