Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
Carbohydr Polym. 2014 Apr 15;104:101-8. doi: 10.1016/j.carbpol.2014.01.031. Epub 2014 Jan 21.
Thermo-induced shape-memory polymers (SMPs) have been widely investigated, but their biomedical applications are limited because their switching temperature does not fall completely within the range of room temperature to body temperature. In this study, we prepared water-induced shape-memory composites composed of microcrystalline cellulose (MCC) and poly(d,l-lactide) (PDLLA). We observed that the composite with an MCC content of 35% (PDLLA-MCC-35) exhibited a good shape-memory effect upon exposure to water at 37°C. We also analyzed the mechanism of the water-triggered shape-memory effect by considering the microstructure, water contact angle, water uptake, thermal properties and static and dynamic mechanical properties of the composite. The results of in vitro degradation analysis demonstrate that the composites exhibited good biodegradation. In addition, Alamar blue assays based on osteoblasts indicate that the composites possess good cytocompatibility. Therefore, the water-induced shape-memory composite can potentially be developed into a new smart medical device.
热致形状记忆聚合物（SMPs）已经得到了广泛的研究，但由于其转变温度不完全在室温到体温范围内，它们在生物医学中的应用受到限制。在这项研究中，我们制备了由微晶纤维素（MCC）和聚（D，L-乳酸）（PDLLA）组成的水致形状记忆复合材料。我们观察到，当暴露在 37°C 的水中时，含有 35%MCC 含量的复合材料（PDLLA-MCC-35）表现出良好的形状记忆效应。我们还通过考虑复合材料的微观结构、水接触角、吸水率、热性能以及静态和动态机械性能，分析了水触发形状记忆效应的机制。体外降解分析的结果表明，复合材料表现出良好的生物降解性。此外，基于成骨细胞的 Alamar blue 测定表明，复合材料具有良好的细胞相容性。因此，水致形状记忆复合材料有望开发成为一种新型智能医疗设备。
