State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, People's Republic of China.
J Mater Chem B. 2019 Jan 7;7(1):123-132. doi: 10.1039/c8tb02462f. Epub 2018 Dec 5.
Shape memory polymers (SMPs) have exhibited great potential in biomedical applications. However, the typical triggers of shape recovery such as heat, UV light, and electricity may be harmful to humans. Accordingly, water-responsive SMPs have become significant, especially for in vivo applications, due to the intrinsic biocompatibility and ready availability of water. However, the reported water-responsive SMPs are limited and relatively complicated. Here, we design a new water-responsive SMP, poly(butanetetrol fumarate) (PBF); the properties of PBF could be modulated by curing. The cured PBF scaffolds exhibited high shape recovery and fixity rates (>95%). PBF showed good biodegradability, and it could support the attachment, viability and alkaline phosphatase activity of osteoblasts. Furthermore, PBF could be readily functionalized via pendant hydroxyl groups, which was demonstrated by the immobilization and controlled release of bone morphogenetic protein 2. We expect that PBF will be useful for various biomedical applications including water-responsive scaffolds, sensors or actuators.
形状记忆聚合物（SMPs）在生物医学应用中表现出巨大的潜力。然而，形状恢复的典型触发因素，如热、紫外线和电，可能对人体有害。因此，水响应性 SMP 变得非常重要，特别是对于体内应用，因为水具有固有生物相容性和易得性。然而，报道的水响应性 SMP 是有限的，而且相对复杂。在这里，我们设计了一种新的水响应性 SMP，即聚丁四醇富马酸酯（PBF）；PBF 的性能可以通过固化来调节。固化的 PBF 支架表现出高形状恢复率和固定率（>95%）。PBF 表现出良好的生物降解性，能够支持成骨细胞的附着、存活和碱性磷酸酶活性。此外，PBF 可以通过悬垂羟基基团进行简便的功能化，这通过骨形态发生蛋白 2 的固定和控制释放得到了证明。我们预计 PBF 将在各种生物医学应用中有用，包括水响应性支架、传感器或执行器。
