Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Carbohydr Polym. 2014 Apr 15;104:231-7. doi: 10.1016/j.carbpol.2014.01.012. Epub 2014 Jan 10.
Super-paramagnetic iron oxide nanoparticles (SPIONPs) were encapsulated at various concentrations within chitosan-triphosphate (SPIONPs-CS) nanoparticles using an ionotropic gelation method. The encapsulation of SPIONPs within CS nanoparticles enhanced their dispersion ability in aqueous solution, with all particles being lower than 130 nm in size and having highly positive surface charge. The SPIONPs-CS nanoparticles exhibited crystalline structure and super-paramagnetic behavior, as seen in non-encapsulated SPIONPs. The morphology of SPIONPs-CS nanoparticles showed that they almost spherical in shape. The effect of phantom environments (culture medium and 3% agar solution) on either T1 or T2 weighted MRI was investigated using a clinical 1.5T MRI scanner. The results revealed that 3% agar solution showed relaxation values higher than the culture medium, leading to a significant decrease in the MR image intensity. Our results demonstrated that the SPIONPs-CS nanoparticles can be applied as tissue-specific MRI contrast agents.
超顺磁性氧化铁纳米粒子（SPIONPs）被包裹在壳聚糖-三磷酸盐（SPIONPs-CS）纳米粒子中，浓度不同，采用离子凝胶法。SPIONPs 在 CS 纳米粒子内的包封增强了其在水溶液中的分散能力，所有颗粒的粒径均低于 130nm，具有高度正表面电荷。SPIONPs-CS 纳米粒子表现出晶态结构和超顺磁性行为，与未包裹的 SPIONPs 相同。SPIONPs-CS 纳米粒子的形态表明它们几乎呈球形。使用临床 1.5T MRI 扫描仪研究了模拟环境（培养基和 3%琼脂溶液）对 T1 或 T2 加权 MRI 的影响。结果表明，3%琼脂溶液的弛豫值高于培养基，导致 MRI 图像强度显著降低。我们的结果表明，SPIONPs-CS 纳米粒子可用作组织特异性 MRI 对比剂。
