Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA, USA.
Neuron. 2014 Mar 5;81(5):961-963. doi: 10.1016/j.neuron.2014.02.024.
Motor neurons in ALS die via cell-autonomous and non-cell-autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al. (2014), in this issue of Neuron, discover that familial and sporadic ALS-derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis, suggesting a new therapeutic avenue.
肌萎缩侧索硬化症中的运动神经元通过细胞自主和非细胞自主机制死亡。在本期《神经元》杂志中，Re 等人使用成人人类星形胶质细胞和运动神经元发现，家族性和散发性肌萎缩侧索硬化症衍生的人类成人星形胶质细胞分泌神经毒性因子，通过坏死性凋亡选择性杀死运动神经元，这为治疗提供了新的途径。
