Vanuytsel L, Feng Y, Landuyt W, Thames H D, van der Schueren E
Department of Experimental Radiotherapy, University Hospital St. -Rafaël, Leuven, Belgium.
Radiother Oncol. 1988 Aug;12(4):333-7. doi: 10.1016/0167-8140(88)90023-0.
The influence of a simultaneous continuous infusion of bleomycin on the time necessary for repair of sublethal radiation damage during fractionated irradiation of mouse lip mucosa was studied. Although there are strong indications that bleomycin interferes with the accumulation and repair of sublethal radiation damage, no significant change in the time course of these repair processes could be demonstrated following various analyses of the experimental results. An interval of at most 4 h between successive irradiations was sufficient to allow for a similar amount of repair of sublethal damage as compared with either 24 h (2 fractions) or 6 h (10 fractions), whether or not radiation was combined with bleomycin infusion.
研究了在小鼠唇黏膜分次照射期间，同时持续输注博来霉素对亚致死性辐射损伤修复所需时间的影响。尽管有强有力的迹象表明博来霉素会干扰亚致死性辐射损伤的积累和修复，但对实验结果进行各种分析后，未发现这些修复过程的时间进程有显著变化。连续照射之间最长间隔4小时，与24小时（2次分割）或6小时（10次分割）相比，足以实现相似程度的亚致死性损伤修复，无论辐射是否与博来霉素输注相结合。
