Landuyt W, Keizer J, Chin A, van der Schueren E
Int J Radiat Oncol Biol Phys. 1987 Sep;13(9):1367-70. doi: 10.1016/0360-3016(87)90231-8.
The influence of CBDCA (JM8) on the radiation-induced mouse lip mucosal reactions has been tested. Both single and fractionated drug doses were used intraperitoneally at 60 mg/kg and 5 X 25 mg/kg respectively. A single injection of CBDCA did not alter the response to a single radiation dose, whether the drug was given at different time intervals from 24 hr prior, to 96 hr after irradiation. A concomitant treatment of daily CBDCA injections and irradiations for 5 consecutive days demonstrated no change of the capacity to repair sublethal radiation damage. When two equal sized radiation doses were separated by 10 days and CBDCA was administered daily from day 3 to 7, the ability to repopulate the lip mucosa epithelium during the radiation-free period was not influenced.
已测试了环磷酰胺（JM8）对辐射诱导的小鼠唇部黏膜反应的影响。分别以60mg/kg的单次剂量和5×25mg/kg的分次剂量腹腔注射给药。单次注射环磷酰胺不会改变对单次辐射剂量的反应，无论药物是在照射前24小时至照射后96小时的不同时间间隔给药。连续5天每日同时注射环磷酰胺和进行照射，结果表明修复亚致死性辐射损伤的能力没有变化。当两个等剂量的辐射剂量间隔10天，且从第3天至第7天每日给予环磷酰胺时，无辐射期唇部黏膜上皮的再增殖能力不受影响。
