Leer J W, Landuyt W, van der Schueren E
Department of Experimental Radiotherapy, University Hospital St. Rafael, Leuven, Belgium.
Radiother Oncol. 1987 Sep;10(1):31-7. doi: 10.1016/s0167-8140(87)80067-1.
The possible interaction of 5-fluorouracil (5-FU) and irradiation on mouse lip mucosa was studied, with special interest for the influence of the route of administration of the drug, either by single intraperitoneal (i.p.) injection or by 7 days continuous subcutaneous infusion. Apart from the possible modification by the drug of radiation-induced damage to the lip mucosa assessment was made of the systemic toxicity. No modification of the radiosensitivity of mouse lip mucosa nor of its repair capacity was observed with the use of 5-FU given either by i.p. injection or by continuous infusion. However, the combination of 5-FU and irradiation resulted in an increased systemic toxicity which was only seen when 5-FU was administered by an i.p. injection in close timing with irradiation. It is suggested that this increased systemic toxicity is caused by the combined effects of irradiation and 5-FU on the alimentary tract, although we could not demonstrate the mechanism of it.
研究了5-氟尿嘧啶（5-FU）与辐射对小鼠唇部黏膜的可能相互作用，特别关注药物给药途径的影响，给药途径为单次腹腔注射或连续7天皮下输注。除了药物对辐射诱导的唇部黏膜损伤可能产生的改变外，还评估了全身毒性。无论是腹腔注射还是连续输注5-FU，均未观察到小鼠唇部黏膜放射敏感性及其修复能力的改变。然而，5-FU与辐射联合使用会导致全身毒性增加，这种情况仅在5-FU腹腔注射且与辐射时间接近时出现。尽管我们无法证明其机制，但提示这种全身毒性增加是由辐射和5-FU对消化道的联合作用引起的。
