被动给予的中和单克隆抗体不能保护犊牛免受牛疱疹病毒1型感染。
Passively administered neutralizing monoclonal antibodies do not protect calves against bovine herpesvirus 1 infection.
作者信息
Marshall R L, Letchworth G J
机构信息
Department of Veterinary Science, University of Wisconsin-Madison 53706.
出版信息
Vaccine. 1988 Aug;6(4):343-8. doi: 10.1016/0264-410x(88)90181-8.
Monoclonal antibodies specific for defined epitopes on the gI, gIII and gIV envelope glycoproteins of BHV-1 were used individually or in glycoprotein-monospecific pools for passive immunization of young calves. Although serum antibody titres comparable to those found in naturally infected and recovered calves were achieved, passive immunization failed to prevent the growth of BHV-1 in nasal and ocular mucosa and did not decrease the duration of viral shedding.
针对牛疱疹病毒1型（BHV-1）gI、gIII和gIV包膜糖蛋白上特定表位的单克隆抗体，单独或在糖蛋白单特异性组合中用于对小牛进行被动免疫。尽管获得了与自然感染并康复的小牛相当的血清抗体滴度，但被动免疫未能阻止BHV-1在鼻和眼黏膜中的生长，也未缩短病毒 shedding的持续时间。
Zotero 插件