Loncar Zoran, Curić Goran, Mestrović Ana Havelka, Mićković Vlatko, Bilić Morana
University of Zagreb, University Hospital Center Sestre Milosrdnice, Cinic for Traumatology, Zagreb, Croatia.
University J. J. Strossmayer, School of Medicine, Laboratory for DNA analysis, Osijek, Croatia.
Coll Antropol. 2013 Dec;37(4):1237-44.
The aim of this study was to analyze the association between single nucleotide polymorphism (SNP) in IL1B (rs1143 634) and IL1RN (rs2234677) with chronic low back pain (LBP) in chronic post-traumatic stress disorder (PTSD). A total of 406 war veterans from 1991-1995 war in Croatia participated in this study. They were divided into four groups, according to psychiatric interview, psychometric testing and the presence of LBP, verified by the imaging of lumbar area, into: (i) war veterans suffering from PTSD and LBP (N = 102), (ii) war veterans suffering from PTSD only (N = 108), (iii) war veterans suffering from LBP only (N = 99) and (iv) healthy controls (N =97). Each subject provided a blood sample for IL1B and IL1RN polymorphism testing. We found no association of rs1143634 in IL1-B with LBP Permutation test showed significant association of rs1143634 in IL1-RN with LBP group and presence of wild type allele A was protective in LBP group. The same SNP (rs1143634) in IL1-B was associated with the intensity of pain. No other associations were observed between these two markers and self-reported measures evaluating PTSD and pain symptoms. These results suggest the potential role of cytokine network in the pathogenesis of chronic PTSD and LBP, although the direct causative pathway remains unclear. The alteration of cytokine network on the level of the brain, spinal medulla and the spine may be responsible for modulation of pain and the occurrence of LBP
本研究旨在分析白细胞介素1β（IL1B，rs1143634）和白细胞介素1受体拮抗剂（IL1RN，rs2234677）中的单核苷酸多态性（SNP）与慢性创伤后应激障碍（PTSD）中的慢性下腰痛（LBP）之间的关联。共有406名来自1991 - 1995年克罗地亚战争的退伍军人参与了本研究。根据精神科访谈、心理测试以及经腰椎区域影像学检查证实的LBP情况，他们被分为四组：（i）患有PTSD和LBP的退伍军人（N = 102），（ii）仅患有PTSD的退伍军人（N = 108），（iii）仅患有LBP的退伍军人（N = 99）和（iv）健康对照组（N = 97）。每个受试者都提供了一份血液样本用于IL1B和IL1RN基因多态性检测。我们发现IL1 - B中的rs1143634与LBP无关联。排列检验显示IL1 - RN中的rs1143634与LBP组有显著关联，野生型等位基因A在LBP组中具有保护作用。IL1 - B中的相同SNP（rs1143634）与疼痛强度相关。在这两个标志物与评估PTSD和疼痛症状的自我报告指标之间未观察到其他关联。这些结果表明细胞因子网络在慢性PTSD和LBP发病机制中可能发挥作用，尽管直接的致病途径仍不清楚。大脑、脊髓和脊柱水平的细胞因子网络改变可能是疼痛调节和LBP发生的原因。
