Institute of Orthopedics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.
J Neurosurg Spine. 2013 Aug;19(2):243-7. doi: 10.3171/2013.4.SPINE12782. Epub 2013 May 31.
Recent studies have suggested that genetic risk factors play an important role in the occurrence of low-back pain (LBP) and lumbar disc disease. The authors' study aimed to assess the association between 3 single-nucleotide polymorphisms (SNPs) and susceptibility to LBP related to military training.
In this case-control study, data from 892 Chinese male soldiers were retrospectively reviewed. The case group was made up of 305 soldiers with LBP related to military training and a control group of 587 soldiers without constant LBP for more than 2 weeks. Genomic DNA was extracted from peripheral blood leukocytes of all subjects and polymerase chain reaction products were genotyped.
No association was found between the SNP of interleukin-1β (IL-1β; +3954C/T) and LBP at both the genotypic (p = 0.104) and the allelic (p = 0.098) level. However, the G allele of caspase-9 (CASP-9) and the T allele of growth differentiation factor 5 (GDF5) were more common in patients with LBP than in patients without LBP (p < 0.001).
The findings in a Chinese military cohort indicated that CASP-9 (-1263A/G) and GDF5 (+104T/C) polymorphisms are associated with a susceptibility to LBP related to military training.
最近的研究表明，遗传风险因素在腰痛（LBP）和腰椎间盘疾病的发生中起着重要作用。作者的研究旨在评估 3 个单核苷酸多态性（SNP）与与军事训练相关的 LBP 易感性之间的关系。
在这项病例对照研究中，回顾性分析了 892 名中国男性士兵的数据。病例组由 305 名因军事训练而患有 LBP 的士兵组成，对照组由 587 名没有持续 2 周以上恒定 LBP 的士兵组成。从所有受试者的外周血白细胞中提取基因组 DNA，并对聚合酶链反应产物进行基因分型。
IL-1β（IL-1β；+3954C/T）SNP 与 LBP 之间无论在基因型（p=0.104）还是等位基因（p=0.098）水平均无关联。然而，与没有 LBP 的患者相比，患有 LBP 的患者中 caspase-9（CASP-9）的 G 等位基因和生长分化因子 5（GDF5）的 T 等位基因更为常见（p<0.001）。
在中国军事队列中的研究结果表明，CASP-9（-1263A/G）和 GDF5（+104T/C）多态性与军事训练相关的 LBP 易感性有关。
