CYP1A1 基因多态性和吸烟状况作为肺癌风险的修饰因素。

CYP1A1 gene polymorphisms and smoking status as modifier factors for lung cancer risk.

机构信息

Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

出版信息

Gene. 2014 May 10;541(1):26-30. doi: 10.1016/j.gene.2014.03.003. Epub 2014 Mar 5.

DOI:10.1016/j.gene.2014.03.003

PMID:24613751

Abstract

OBJECTIVE

Lung cancer remains the most prevalent malignancy worldwide. Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphic genes. Several metabolic enzymes are currently under investigation for their possible role in lung cancer susceptibility, including members of the cytochrome P450 (CYP) superfamily. The aim of this work was to identify the correlation between CYP1A1 m1 and m2 polymorphisms and lung cancer risk and figure its interactions with smoking as genetic modifiers in the etiology of lung cancer in the Egyptian population.

MATERIALS AND METHODS

One hundred and ten patients with lung cancer and one hundred and ten controls were enrolled in the study. CYP1A1 m1 and m2 polymorphisms were determined using polymerase chain reaction restriction fragment length polymorphism.

RESULTS

Subjects carrying TC and CC genotypes of CYP1A1 m1 and AG and GG genotypes of CYP1A1 m2 were significantly more likely to develop lung cancer especially squamous cell carcinoma. The proportion of lung cancer attributable to the interaction of smoking and CYP1A1 m1 and CYP1A1 m2 polymorphisms was 32% and 52% respectively.

CONCLUSION

Our results revealed that CYP1A1 m1 and m2 polymorphisms contribute to smoking related lung cancer risk in the Egyptian population.

摘要

目的

肺癌仍然是全球最常见的恶性肿瘤。遗传多态性基因的存在被证明可调节肺癌的易感性。目前正在研究几种代谢酶在肺癌易感性中的可能作用，包括细胞色素 P450（CYP）超家族的成员。本研究旨在确定 CYP1A1 m1 和 m2 多态性与肺癌风险之间的相关性，并研究其与吸烟的相互作用，作为遗传修饰因子在埃及人群肺癌发病机制中的作用。