Cao DeHong, Ren ZhengJu, Lu DongLiang, Liu LiangRen, Xu Peng, Zhang Qin, Wei Qiang
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu.
Department of Urology.
Medicine (Baltimore). 2019 Aug;98(31):e16543. doi: 10.1097/MD.0000000000016543.
Number of studies have been performed to investigate the relationship between the CYP1A1 rs4646903 polymorphism and male infertility risk, but the sample size was small and the results were conflicting. A meta-analysis was performed to assess these associations.
A systematic search was conducted to identify all relevant studies from Medline, Web of science, Embase, China biology medical literature database (CBM), China National Knowledge Infrastructure (CNKI), WanFang and Weipu (VIP) databases up to June 30, 2018. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of associations. All of the statistical analyses were conducted using Revman 5.3 and Stata 14.0.
Ten studies involved 3028 cases and 3258 controls. Overall, significant association was observed between the CYP1A1 rs4646903 polymorphism and male infertility (C vs T: OR = 1.42, 95%CI = 1.14-1.76; CC vs TT: OR = 2.13, 95%CI = 1.36-3.34; CC vs CT+TT: OR = 1.96, 95%CI = 1.30-2.95; CC+CT vs TT: OR = 1.51, 95%CI = 1.16-1.97). In subgroup analysis by ethnic group, a statistically significant association was observed in Asians (C vs T: OR = 1.59, 95%CI = 1.22-2.08), but not in Non-Asians (C vs T: OR = 1.01, 95%CI = 0.79-1.30). Additionally, none of the individual studies significantly affected the association between CYP1A1 rs4646903 polymorphism and male infertility, according to sensitivity analysis.
Our meta-analysis supports that the CYP1A1 rs4646903 polymorphism might contribute to individual susceptibility to male infertility in Asians.
已有多项研究探讨细胞色素P450 1A1（CYP1A1）基因rs4646903多态性与男性不育风险之间的关系，但样本量较小且结果相互矛盾。因此进行了一项荟萃分析以评估这些关联。
进行系统检索，以识别截至2018年6月30日来自Medline、科学网、Embase、中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方和维普（VIP）数据库的所有相关研究。计算比值比（OR）及95%置信区间（CI）以评估关联强度。所有统计分析均使用Revman 5.3和Stata 14.0进行。
10项研究共纳入3028例病例和3258例对照。总体而言，观察到CYP1A1 rs4646903多态性与男性不育之间存在显著关联（C vs T：OR = 1.42，95%CI = 1.14 - 1.76；CC vs TT：OR = 2.13，95%CI = 1.36 - 3.34；CC vs CT + TT：OR = 1.96，95%CI = 1.30 - 2.95；CC + CT vs TT：OR = 1.51，95%CI = 1.16 - 1.97）。在按种族分组的亚组分析中，亚洲人群中观察到具有统计学意义的关联（C vs T：OR = 1.59，95%CI = 1.22 - 2.08），而非亚洲人群中未观察到（C vs T：OR = 1.01，95%CI = 0.79 - 1.30）。此外，根据敏感性分析，没有任何一项个体研究显著影响CYP1A1 rs4646903多态性与男性不育之间的关联。
我们的荟萃分析支持CYP1A1 rs4646903多态性可能导致亚洲人个体对男性不育的易感性增加。
