Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Pediatr Blood Cancer. 2014 Jun;61(6):1129-1131. doi: 10.1002/pbc.24930. Epub 2014 Jan 13.
International Classification of Diseases, 9th Revision (ICD-9) code(s) for neuroblastoma do not exist, preventing identification of these patients in administrative databases. To overcome this challenge, a three-step algorithm, using ICD-9 codes, exclusion criteria, and manual review of chemotherapy billing data, was utilized to assemble a high-risk neuroblastoma cohort (n = 952) from the Pediatric Health Information System (PHIS) Database and validated at a single institution [sensitivity 89.1%; positive predictive value (PPV) 96.1%]. This cohort provides a data source for future comparative effectiveness and clinical epidemiology studies in high-risk neuroblastoma patients.
国际疾病分类第 9 版（ICD-9）代码不存在，这使得在管理数据库中无法识别这些患者。为了克服这一挑战，我们使用 ICD-9 代码、排除标准和化疗计费数据的手动审查，采用三步算法，从儿科健康信息系统（PHIS）数据库中组建了高危神经母细胞瘤队列（n=952），并在单个机构进行了验证[敏感性 89.1%；阳性预测值（PPV）96.1%]。该队列为高危神经母细胞瘤患者的未来比较有效性和临床流行病学研究提供了数据来源。
