Li Zhaolong, Chen Yingchao, Yan Fubo, Zhang Qingyuan, Zhou Jie, Yang Jizhou
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Nov;27(21):1184-7.
To investigate the expression and clinical significance of BUB1 protein in laryngeal squa mous cell carcinoma (LSCC) tissues.
The expression of BUB1 protein was measured by immunohistochemistry (EliVision two steps) in 55 cases of LSCC tissues,30 cases of adjacent normal laryngeal mucosa tissues, the relationship of BUB1 expression with clinical pathologic factors in LSCC was also analyzed.
The positive rate of BUB1 protein in LSCC tissues (50.9%, 28/55) was significantly lower than that in adjacent normal laryngeal mucosa tissues (83.3%, 25/30), P < 0.01. The positive rate of BUB1 protein was correlated with differentiation grading and lymph node metastasis of LSCC (P < 0.05, respectively), but not with patient's sex, age, smoking, tumor site, T-stage and clinical stage(P > 0.05, respectively).
The low expresssion of BUB1 protein is closely related to the tumorigenesis and development of LSCC, and can be a molecular marker for prognosticating metastasis and prognosis of LSCC.
探讨BUB1蛋白在喉鳞状细胞癌（LSCC）组织中的表达及临床意义。
采用免疫组织化学（EliVision两步法）检测55例LSCC组织、30例癌旁正常喉黏膜组织中BUB1蛋白的表达，并分析LSCC中BUB1表达与临床病理因素的关系。
LSCC组织中BUB1蛋白阳性率为50.9%（28/55），显著低于癌旁正常喉黏膜组织的83.3%（25/30），P<0.01。BUB1蛋白阳性率与LSCC的分化程度和淋巴结转移相关（P均<0.05），但与患者性别、年龄、吸烟情况、肿瘤部位、T分期及临床分期无关（P均>0.05）。
BUB1蛋白低表达与LSCC的发生发展密切相关，可作为预测LSCC转移及预后的分子标志物。
