The Photobiology Unit, Ninewells Hospital and Medical School, Dundee, DD1 9SY, U.K.
Br J Dermatol. 2014 Mar;170(3):694-8. doi: 10.1111/bjd.12719.
Patients with lupus erythematosus (LE) are often abnormally photosensitive. Ultraviolet (UV) exposure can not only induce cutaneous lesions but may also contribute to systemic flares and disease progression. Various forms of energy-efficient lighting have been shown to emit UV radiation.
To determine the effects of these emissions on individuals with LE.
This assessment investigated cutaneous responses to repeated exposures from three types of lighting: compact fluorescent lamp (CFL), light-emitting diode (LED) and energy-efficient halogen (EEH). The subjects were 15 patients with LE and a control group of five healthy volunteers.
No cutaneous LE lesions were induced by any of the light sources. Delayed skin erythema was induced at the site of CFL irradiation in six of the 15 patients with LE and two of the five healthy subjects. Erythema was increased in severity and more persistent in patients with LE. One patient with LE produced a positive delayed erythema to the EEH. A single patient with LE produced immediate abnormal erythemal responses to the CFL, LED and EEH. Further investigation revealed that this patient also had solar urticaria. All other subjects had negative responses to LED exposure.
Compact fluorescent lamps emit UV that can induce skin erythema in both individuals with LE and healthy individuals when situated in close proximity. However, this occurs to a greater extent and is more persistent in patients with LE. EEHs emit UVA that can induce erythema in patients with LE. LEDs provide a safer alternative light source without risk of UV exposure.
红斑狼疮（LE）患者通常对光异常敏感。紫外线（UV）暴露不仅会引起皮肤损伤，还可能导致全身发作和疾病进展。各种节能照明形式都已被证明会发出 UV 辐射。
确定这些辐射对 LE 患者的影响。
本评估研究了三种照明类型（紧凑型荧光灯（CFL）、发光二极管（LED）和节能卤素灯（EEH））重复照射对皮肤的反应。研究对象为 15 名 LE 患者和五名健康志愿者对照组。
任何光源均未引起皮肤 LE 病变。在 15 名 LE 患者中的 6 名和 5 名健康受试者中的 2 名中，CFL 照射部位诱导出迟发性皮肤红斑。LE 患者的红斑严重程度增加且更持久。一名 LE 患者对 EEH 产生了阳性迟发性红斑。一名 LE 患者对 CFL、LED 和 EEH 产生了立即异常红斑反应。进一步调查显示，该患者还患有日光性荨麻疹。所有其他受试者对 LED 照射均无反应。
紧凑型荧光灯发出的 UV 可以在靠近时在 LE 患者和健康个体中引起皮肤红斑。然而，LE 患者的红斑程度更大且更持久。EEH 发出的 UVA 可以引起 LE 患者的红斑。LED 提供了一种更安全的替代光源，没有 UV 暴露的风险。
