低热量摄入的肥胖个体和高热量摄入的非肥胖个体中血清鸢尾素水平、身体活动与代谢综合征生物标志物之间的关系。
Relationship of serum irisin levels, physical activity, and metabolic syndrome biomarkers in obese individuals with low-calorie intake and non-obese individuals with high-calorie intake.
作者信息
Hejazi Jalal, Ghobadian Bijan, Ghasemi Nasrin, Sadeh Hossein, Abedimanesh Nasim, Rahimlou Mehran
机构信息
Social Determinants of Health Research Center, Health and Metabolic Diseases Research Institute , Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Nutrition, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
出版信息
J Health Popul Nutr. 2025 Jan 2;44(1):2. doi: 10.1186/s41043-024-00730-0.
BACKGROUND
Despite all the advances in our knowledge regarding obesity, our understanding of its etiology is still far from complete. This study aimed to evaluate the association of serum irisin levels with physical activity and some of the metabolic syndrome-related biomarkers among obese people with low-calorie intake and non-obese people with high-calorie intake.
METHODS
Obese and non-obese healthy individuals with respectively low and high-calorie intakes were recruited. Irisin and other biomarkers were measured using standard biochemical methods. Participants' physical activity was evaluated by administering the International Physical Activity Questionnaire (IPAQ). To analyze the body composition of the participants, a standard body composition device (ioi 353) was applied. Logistic regression was used to calculate the odds ratio (OR) and to examine the effect of confounders such as age, sex, genetics, and activity.
RESULTS
Data from the seventy-seven participants were included in the final analysis. The mean age of the participants in the obese and non-obese groups was 38.33 ± 14.88 and 30.24 ± 13.37 years, respectively. Participants in the obese group had lower physical activity compared to the non-obese group (3395.38 ± 2801 MET-min/week vs. 6015.18 ± 3178 MET-min/week; p < 0.001). The Irisin concentration in the obese and non-obese groups was 7.84 ± 2.49 ng/ml and 8.06 ± 1.89 ng/ml, respectively, which wasn't significantly different (p = 0.66). We observed a noteworthy and favorable association between irisin concentration and total body water (TBW), lean body mass (LBM), and soft lean mass (SLM) in the non-obese group.
CONCLUSIONS
These data indicated that although obese participants were relatively inactive compared to non-obese individuals, circulating irisin level wasn't significantly different between the two groups.
背景
尽管我们对肥胖的认识有了诸多进展，但对其病因的理解仍远未完善。本研究旨在评估低热量摄入的肥胖人群和高热量摄入的非肥胖人群中血清鸢尾素水平与身体活动及一些代谢综合征相关生物标志物之间的关联。
方法
招募了分别摄入低热量和高热量的肥胖及非肥胖健康个体。使用标准生化方法测量鸢尾素和其他生物标志物。通过发放国际体力活动问卷（IPAQ）评估参与者的身体活动情况。应用标准身体成分测量仪（ioi 353）分析参与者的身体成分。采用逻辑回归计算优势比（OR）并检验年龄、性别、遗传和活动等混杂因素的影响。
结果
七十七名参与者的数据纳入最终分析。肥胖组和非肥胖组参与者的平均年龄分别为38.33±14.88岁和30.24±13.37岁。肥胖组参与者的身体活动水平低于非肥胖组（3395.38±2801代谢当量-分钟/周对6015.18±3178代谢当量-分钟/周；p<0.001）。肥胖组和非肥胖组的鸢尾素浓度分别为7.84±2.49 ng/ml和8.06±1.89 ng/ml，差异无统计学意义（p = 0.66）。我们在非肥胖组中观察到鸢尾素浓度与总体水（TBW）、瘦体重（LBM）和瘦软组织质量（SLM）之间存在显著且有益的关联。
结论
这些数据表明，尽管肥胖参与者相对于非肥胖个体活动较少，但两组之间循环鸢尾素水平差异无统计学意义。
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