针对英国育龄女性的碘特异性简短食物频率问卷的验证。

Validation of a short food frequency questionnaire specific for iodine in U.K. females of childbearing age.

作者信息

Combet E, Lean M E J

机构信息

Human Nutrition, School of Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.

出版信息

J Hum Nutr Diet. 2014 Dec;27(6):599-605. doi: 10.1111/jhn.12219. Epub 2014 Mar 13.

DOI:10.1111/jhn.12219

PMID:24620754

Abstract

BACKGROUND

Widespread subclinical iodine insufficiency has recently been reported in Europe, based on urinary iodine using World Health Organization/Food and Agriculture Organization criteria, in particular among young women. Although urinary iodine concentration (UIC) is a useful measurement of the iodine status in a population, it does not provide an insight into the habitual iodine intake of this population. This is compounded by the fact that very few iodine-specific food frequency questionnaires (FFQ) have been validated so far. The present study aimed to develop and validate a new, simple, rapid survey tool to assess dietary iodine exposure in females of childbearing age.

METHODS

Iodine was measured in a duplicate 24-h urine collection. Iodine intake was measured with duplicate 4-day semi-quantitative food diaries and the FFQ. Correlation, cross-classification and Bland-Altman analyses were used to estimate agreement, bias and the reliability of the method. The triangular (triad) method was used to calculate validity coefficients.

RESULTS

Forty-three women, aged 19-49 years, took part in the validation of the 17-items FFQ. Median (interquartile range) UIC was 74 (47-92) μg L(-1) , which is indicative of mild iodine insufficiency. The FFQ showed good agreement with food diaries with respect to classifying iodine intake (82% of subjects were classified in the same or adjacent quartile). The FFQ was moderately correlated with the food diaries (rs = 0.45, P = 0.002) and urinary excretion in μg L(-1) (rs = 0.34, P = 0.025) but not in μg day(-1) (P = 0.316). The validity coefficients were 0.69, 0.66 and 0.52 for the food diaries, FFQ and urinary iodine excretion, respectively.

CONCLUSIONS

The FFQ provides a rapid and reliable estimate of dietary iodine exposure to identify those population subgroups at risk of iodine deficiency.

摘要

背景

最近有报道称，根据世界卫生组织/联合国粮食及农业组织的标准，基于尿碘情况，欧洲存在广泛的亚临床碘缺乏现象，尤其是在年轻女性中。尽管尿碘浓度（UIC）是衡量人群碘状况的一个有用指标，但它无法深入了解该人群的习惯性碘摄入量。到目前为止，很少有针对碘的食物频率问卷（FFQ）得到验证，这使得情况更加复杂。本研究旨在开发并验证一种新的、简单、快速的调查工具，以评估育龄女性的膳食碘摄入量。

方法

通过收集24小时双份尿液来测量碘含量。采用双份4天半定量食物日记和食物频率问卷来测量碘摄入量。使用相关性分析、交叉分类分析和布兰德-奥特曼分析来估计一致性、偏差和方法的可靠性。采用三角（三联）法计算效度系数。

结果

43名年龄在19至49岁之间的女性参与了17项食物频率问卷的验证。UIC中位数（四分位间距）为74（47 - 92）μg/L，表明存在轻度碘缺乏。在碘摄入量分类方面，食物频率问卷与食物日记显示出良好的一致性（82%的受试者被归类在相同或相邻的四分位数区间）。食物频率问卷与食物日记呈中度相关（rs = 0.45，P = 0.002），与尿碘排泄量（μg/L）呈中度相关（rs = 0.34，P = 0.025），但与尿碘排泄量（μg/天）无相关性（P = 0.316）。食物日记、食物频率问卷和尿碘排泄量的效度系数分别为0.69、0.66和0.52。