School of Food and Nutritional Sciences, University College Cork, Cork, Republic of Ireland.
INFANT Research Centre, University College Cork, Cork, Republic of Ireland.
J Hum Nutr Diet. 2024 Jun;37(3):633-642. doi: 10.1111/jhn.13289. Epub 2024 Feb 18.
Adequate iodine status is critical for thyroid hormone synthesis, which is essential for foetal brain development. Suboptimal iodine status has been reported in young women across Europe. Although urinary iodine concentration (UIC) is a good indicator of recent exposure, it does not reflect habitual iodine intake. This study aimed to develop and validate an iodine-specific food frequency questionnaire (I-FFQ) to assess habitual intake in Irish women aged 18-50 years.
A 47-item interviewer-administered I-FFQ, informed by national food consumption data on Irish women aged 18-35 years, was developed and validated in a study of 100 nonpregnant women using a 4-day weighed food diary (FD) and UIC as the reference methods. Correlation, cross-classification and Bland-Altman analyses were used to assess agreement and bias between the I-FFQ and FD. Validity coefficients were calculated using the method of triads.
Median (interquartile range [IQR]) UIC was 82 (49, 139) µg/L. Median (IQR) intakes were 161 (106, 217) and 133 (98, 182) µg/day for the I-FFQ and FD, respectively (p = 0.001). Estimates were moderately correlated (r = 0.434), and the I-FFQ classified 89% of participants into the same or adjacent tertile of intake as the FD. Validity coefficients for the I-FFQ, FD and UIC were 0.542, 0.800 and 0.228, respectively. Though repeatability analyses 10 weeks later (n = 69) showed slight differences in estimates of intake (I-FFQ1: 164 (104, 210) µg/day; I-FFQ2: 132 (67, 237) µg/day), intakes were highly correlated between administrations (r = 0.627, p = 0.001).
The I-FFQ provides a reasonable estimate of habitual iodine intake in young women.
足够的碘状态对甲状腺激素的合成至关重要，而甲状腺激素的合成对胎儿大脑发育是必需的。据报道，欧洲年轻女性的碘状态并不理想。虽然尿碘浓度（UIC）是近期暴露的良好指标，但它并不能反映习惯性碘摄入。本研究旨在开发和验证一种专门针对碘的食物频率问卷（I-FFQ），以评估爱尔兰 18-50 岁女性的习惯性碘摄入量。
根据爱尔兰 18-35 岁女性的国家食物消费数据，开发并验证了一个 47 项访谈者管理的 I-FFQ，该问卷在一项研究中使用了 4 天的称重食物日记（FD）和 UIC 作为参考方法，对 100 名非孕妇进行了验证。使用相关、交叉分类和 Bland-Altman 分析来评估 I-FFQ 和 FD 之间的一致性和偏差。使用三联法计算效度系数。
中位数（四分位距 [IQR]）UIC 为 82（49，139）µg/L。I-FFQ 和 FD 的中位数（IQR）摄入量分别为 161（106，217）和 133（98，182）µg/天（p=0.001）。估计值中度相关（r=0.434），I-FFQ 将 89%的参与者归入与 FD 相同或相邻的摄入量三分位组。I-FFQ、FD 和 UIC 的效度系数分别为 0.542、0.800 和 0.228。尽管 10 周后（n=69）的重复性分析显示摄入量的估计值略有不同（I-FFQ1：164（104，210）µg/天；I-FFQ2：132（67，237）µg/天），但两次测试之间的摄入量高度相关（r=0.627，p=0.001）。
I-FFQ 可合理估计年轻女性的习惯性碘摄入量。
