Gómez Selgas Aida, Bexfield Nicholas, Scase Timothy J, Holmes Mark A, Watson Penny
1Aida Gómez Selgas, Animal Health Trust, Lanwades Park, Newmarket, CB8 7UU, United Kingdom.
J Vet Diagn Invest. 2014 Mar;26(2):246-51. doi: 10.1177/1040638713520602. Epub 2014 Mar 12.
Total serum bilirubin (TBIL) is used as a prognostic factor in chronic hepatitis (CH) in human beings. To date, the authors are unaware of any studies looking at the value of TBIL as a prognostic factor in idiopathic canine CH. The objective of the current study was to assess if TBIL is a negative prognostic factor in idiopathic canine CH, and to identify other prognostic factors. Thirty-nine dogs with histologically confirmed idiopathic CH admitted to 2 referral centers between 1999 and 2010 were included in the study. Patients with concurrent diseases that could affect TBIL or the survival time were excluded. Total serum bilirubin was measured prior to liver biopsy, and CH was diagnosed according to standardized histological criteria. Survival time was calculated from time of diagnosis to time of death or euthanasia. Cox proportional hazard analysis was performed to identify prognostic factors. The mean survival time for the 39 dogs included in the analysis was 197 days (1-2,677), and the mean total serum bilirubin was 11 μmol/l (2-265). Total serum bilirubin was statistically significantly associated with survival (odds ratio = 1.082, P = 0.047) as were weight (odds ratio = 1.028, P = 0.028) and the presence of ascites (odds ratio = 6.758, P = 0.013). The current study demonstrates that TBIL could be used as an additional prognostic factor in canine CH.
血清总胆红素(TBIL)被用作人类慢性肝炎(CH)的预后因素。迄今为止,作者尚未发现有任何研究探讨TBIL作为特发性犬类CH预后因素的价值。本研究的目的是评估TBIL是否为特发性犬类CH的不良预后因素,并确定其他预后因素。本研究纳入了1999年至2010年间入住2个转诊中心、经组织学确诊为特发性CH的39只犬。排除患有可能影响TBIL或生存时间的并发疾病的患者。在肝活检前测量血清总胆红素,并根据标准化组织学标准诊断CH。计算从诊断时间到死亡或安乐死时间的生存时间。进行Cox比例风险分析以确定预后因素。纳入分析的39只犬的平均生存时间为197天(1 - 2,677天),血清总胆红素平均为11 μmol/l(2 - 265 μmol/l)。血清总胆红素与生存具有统计学显著相关性(比值比 = 1.082,P = 0.047),体重(比值比 = 1.028,P = 0.028)和腹水的存在(比值比 = 6.758,P = 0.013)也是如此。本研究表明,TBIL可作为犬类CH的额外预后因素。