白细胞介素-22在肝脏疾病中的作用。
Role of interleukin-22 in liver diseases.
作者信息
Pan Chun-xiao, Tang Jie, Wang Xiao-yu, Wu Fan-rong, Ge Jin-fang, Chen Fei-hu
机构信息
School of Pharmacy, Anhui Medical University, 81 Mei-shan Road, Hefei, 230032, China.
出版信息
Inflamm Res. 2014 Jul;63(7):519-25. doi: 10.1007/s00011-014-0727-3. Epub 2014 Mar 13.
INTRODUCTION
Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others.
MATERIALS AND METHODS
A PubMed and Web of Science databases search was performed for studies providing evidences on the role of IL-22 in liver diseases.
CONCLUSION
IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22 receptor 1 and IL-10 receptor 2. This review concisely summarizes the role of IL-22 in the development progression of liver disease of different etiologies. It is focused mainly on the IL-22 intracellular signaling and its influence on liver diseases.
引言
白细胞介素（IL）-22最初被称为IL-10相关T细胞衍生诱导因子（IL-TIF），是IL-10样细胞因子家族的成员。IL-22由Th17细胞高度表达，并与慢性炎症密切相关，包括炎症性肠病和局部肠道炎症等。
材料与方法
对PubMed和Web of Science数据库进行检索，以查找提供IL-22在肝脏疾病中作用证据的研究。
结论
在许多啮齿动物模型中，IL-22通过靶向表达高水平IL-22受体1和IL-10受体2的肝细胞，在改善肝损伤方面发挥重要作用。本综述简要总结了IL-22在不同病因肝病发生发展中的作用。它主要关注IL-22的细胞内信号传导及其对肝脏疾病的影响。
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