印度北部人群中冠心病患者和正常个体幽门螺杆菌、巨细胞病毒及肺炎衣原体免疫球蛋白血清阳性率

Prevalence of Helicobacter pylori, cytomegalovirus, and Chlamydia pneumoniae immunoglobulin seropositivity in coronary artery disease patients and normal individuals in North Indian population.

作者信息

Tewari Rohit, Nijhawan Vs, Mishra Mn, Dudeja Puja, Salopal Tk

机构信息

Classified Specialist (Pathology), Level 3 Hospital (MONUSCO), Congo.

Director MS (PS), O/o DGMS, L Block, MOD, New Delhi.

出版信息

Med J Armed Forces India. 2012 Jan;68(1):53-7. doi: 10.1016/S0377-1237(11)60121-4. Epub 2012 Jan 18.

DOI:10.1016/S0377-1237(11)60121-4

PMID:24623916

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3862904/

Abstract

BACKGROUND

In present day atherosclerosis is perceived as a chronic inflammatory vascular condition and infectious diseases are believed to contribute to its pathophysiology. In this context, the microorganisms which are believed to play a role in the pathophysiology include Chlamydia pneumoniae, cytomegalovirus (CMV), and Helicobacter pylori.

METHOD

A case control study (retrospective) was conducted over a two-year period. The study population was divided into two groups with 200 individuals in each group. The first group comprised cases of coronary artery disease (CAD) and the second comprised healthy controls selected from the general population after matching for age and sex. Enzyme-linked immunosorbent assay (ELISA) was done for immunoglobulin (IgG) antibodies to H. pylori, C. pneumonia, and CMV. They were also evaluated for conventional risk factors including hypertension, diabetes, obesity, and dyslipidaemia. Epi Info™ version 6 six software was used for analysis of data. Odds ratio, χ(2) for trend and multiple logistic regression analysis were used to find out statistically significant results.

RESULTS

Seropositivity for H. pylori was present in 119 patients of CAD (59.5%) but it was present in only 76 controls (38%) (P = 0.001). There was a statistically significant association between seropositivity for H. pylori and CAD. There was no statistically significant association between C. pneumoniae and CMV seropositivity with CAD. Multiple logistic regression analysis was done with CAD as the outcome (dependent variable). The predictor covariates (independent) variables were seropositivity to H. pylori, C. pneumoniae, and CMV, hypertension, obesity, diabetes, and dyslipidaemia. It was found that seropositivity to H. pylori, hypertension, obesity, and dyslipidaemia were significant risk factors for CAD.

CONCLUSION

Our study shows an association between IgG antibody response to H. pylori and CAD. Multiple logistic regression analysis showed that this association was retained even on comparison with the other risk factors.

摘要

背景

在当今，动脉粥样硬化被视为一种慢性炎症性血管疾病，并且传染病被认为对其病理生理学有影响。在这种情况下，被认为在病理生理学中起作用的微生物包括肺炎衣原体、巨细胞病毒（CMV）和幽门螺杆菌。

方法

进行了一项为期两年的病例对照研究（回顾性）。研究人群分为两组，每组200人。第一组包括冠状动脉疾病（CAD）病例，第二组包括在年龄和性别匹配后从普通人群中选取的健康对照。对幽门螺杆菌、肺炎衣原体和CMV的免疫球蛋白（IgG）抗体进行酶联免疫吸附测定（ELISA）。他们还被评估了包括高血压、糖尿病、肥胖和血脂异常在内的传统危险因素。使用Epi Info™ 6版软件进行数据分析。采用比值比、趋势χ(2)检验和多因素逻辑回归分析来得出具有统计学意义的结果。

结果

119例CAD患者（59.5%）存在幽门螺杆菌血清阳性，但仅76例对照（38%）存在幽门螺杆菌血清阳性（P = 0.001）。幽门螺杆菌血清阳性与CAD之间存在统计学显著关联。肺炎衣原体和CMV血清阳性与CAD之间无统计学显著关联。以CAD为结局（因变量）进行多因素逻辑回归分析。预测协变量（自变量）为幽门螺杆菌、肺炎衣原体和CMV血清阳性、高血压、肥胖、糖尿病和血脂异常。发现幽门螺杆菌血清阳性、高血压、肥胖和血脂异常是CAD的显著危险因素。