Broenen Emmi, Mavinkurve-Groothuis Annelies, Kamphuis-van Ulzen Karin, Brüggemann Roger, Verweij Paul, Warris Adilia
Department of Pediatrics, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Department of Radiology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Med Mycol Case Rep. 2014 Feb 20;4:8-11. doi: 10.1016/j.mmcr.2014.02.001. eCollection 2014 Apr.
The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.
现有的侵袭性肺曲霉病管理指南不建议对肺外部位进行筛查。由于中枢神经系统（CNS）曲霉病的存在会影响关于使用哪种抗真菌药物以及血浆中唑类药物目标浓度的治疗决策，因此了解感染是否播散至中枢神经系统是绝对必要的。我们证明了需要一种结构化方法来筛查儿科患者的中枢神经系统曲霉病。
