Vohra R, Drury J K, Shapiro D, Shenkin A, Pollock J G
Peripheral Vascular Surgical Unit, Glasgow Royal Infirmary, Scotland.
Ann Vasc Surg. 1987 Dec;1(5):548-51. doi: 10.1016/S0890-5096(06)61438-6.
Twenty patients were randomized to receive either an untreated Dacron aortic bifurcation graft (n = 10), or a similar graft impregnated with gelatin (n = 10). Venous blood samples were taken preoperatively and at frequent intervals until five weeks after surgery. C-reactive protein (normal range less than 10 mg/l) and alpha l-acid glycoprotein (normal range 0.3-1.0 g/l) were measured. The peak mean value of C-reactive protein for the sealed group was 226.3 +/- 49.2 mg/l and 221.3 +/- 56.4 mg/l for the unsealed group. The corresponding values for alpha 1-acid glycoprotein were 1.49 +/- 0.25 g/l and 1.44 +/- 0.3 g/l. The C-reactive protein response returned more quickly to normal, with only two patients in each group having a slightly elevated response after four weeks, while the value for alpha l-acid glycoprotein remained elevated at five weeks for the same two patients in each group. There was no significant difference between the serum acute phase protein response in either group. This suggests that a knitted Dacron graft sealed with gelatin does not exaggerate the inflammatory response.
20名患者被随机分为两组，一组接受未处理的涤纶主动脉分叉移植物（n = 10），另一组接受浸渍明胶的类似移植物（n = 10）。术前及术后频繁采集静脉血样，直至术后五周。检测C反应蛋白（正常范围小于10mg/l）和α1-酸性糖蛋白（正常范围0.3 - 1.0g/l）。密封组C反应蛋白的峰值平均值为226.3±49.2mg/l，未密封组为221.3±56.4mg/l。α1-酸性糖蛋白的相应值分别为1.49±0.25g/l和1.44±0.3g/l。C反应蛋白反应恢复正常更快，每组只有两名患者在四周后反应略有升高，而每组相同的两名患者在五周时α1-酸性糖蛋白值仍升高。两组血清急性期蛋白反应之间无显著差异。这表明用明胶密封的针织涤纶移植物不会夸大炎症反应。
