Utoh J, Miyauchi Y, Goto H, Obayashi H, Hirata T
First Department of Surgery, Kumamoto University School of Medicine, Japan.
Surg Today. 1996;26(4):258-61. doi: 10.1007/BF00311584.
Despite widespread use of the gelatin-sealed knitted Dacron prosthesis (GDP) in clinical practice owing to its zero porosity, the biological impacts of this graft are still controversial. We conducted a randomized controlled study on 50 patients undergoing abdominal aortic aneurysm repair to evaluate the inflammatory reaction to GDP (n = 25) and unsealed knitted Dacron prostheses (UDP, n = 25). There were no significant differences in the mean age, size of the aneurysm, operative time, blood loss, or transfusion requirements between the GDP and UDP groups. During the first 7 postoperative days (PODs), slight fever and leukocytosis were noticed in both groups. Significant differences in maximum body temperature, leukocyte count, and plasma C-reactive protein concentration were observed between the GDP and UDP groups on POD 14:37.2 +/- 0.5 degrees C vs 36.9 +/- 0.3 degrees C (P = 0.019), 8,151 +/- 1,788/microliters vs 6,914 +/- 1,501/microliters (P = 0.015), and 32.6 +/- 27.5 mg/l vs 19.0 +/- 15.8 mg/l (P = 0.048), respectively. By POD 21, however, there were no detectable differences in these variables. Thus, we concluded that GDP caused an inflammatory reaction in the 2nd week after implantation, but ultimately there were no significant differences from UDP by the 3rd week.
尽管由于其零孔隙率，明胶密封针织涤纶人工血管（GDP）在临床实践中得到了广泛应用，但其生物学影响仍存在争议。我们对50例接受腹主动脉瘤修复术的患者进行了一项随机对照研究，以评估对GDP（n = 25）和未密封针织涤纶人工血管（UDP，n = 25）的炎症反应。GDP组和UDP组在平均年龄、动脉瘤大小、手术时间、失血量或输血需求方面没有显著差异。术后第1周内，两组均出现轻微发热和白细胞增多。在术后第14天，GDP组和UDP组在最高体温、白细胞计数和血浆C反应蛋白浓度方面存在显著差异：分别为37.2±0.5℃ 对36.9±0.3℃（P = 0.019），8151±1788/微升对6914±1501/微升（P = 0.015），以及32.6±27.5毫克/升对19.0±15.8毫克/升（P = 0.048）。然而，到术后第21天，这些变量没有可检测到的差异。因此，我们得出结论，GDP在植入后第2周引起炎症反应，但到第3周时与UDP最终没有显著差异。
