活性维生素D3不会抑制损伤后G0期细胞的募集。

Active vitamin D3 does not suppress recruitment of G0 cells following injury.

作者信息

van Bokhoven M G, de Mare S, Czarnetzki B M, van Erp P E, Boezeman J B, van de Kerkhof P C

机构信息

Department of Dermatology, University of Nijmegen, The Netherlands.

出版信息

Br J Dermatol. 1988 Dec;119(6):737-42. doi: 10.1111/j.1365-2133.1988.tb03496.x.

DOI:10.1111/j.1365-2133.1988.tb03496.x

PMID:2462445

Abstract

The effect of topically applied active vitamin D3 on epidermal regeneration was studied in eight healthy volunteers following sellotape stripping. The mobilization of resting (Go) cells was assessed by means of DNA flow cytometry, using a narrow window in the mid-S phase to monitor the progress of the recruited cells. Although vitamin D3 was applied at a concentration exceeding the range reported to be effective in psoriasis, we were unable to find any effect of active vitamin D3 on Go mobilization in vivo.

摘要

在八名健康志愿者进行透明胶带剥脱后，研究了局部应用活性维生素D3对表皮再生的影响。通过DNA流式细胞术评估静止（G0）细胞的动员情况，利用S期中期的狭窄窗口监测募集细胞的进展。尽管应用的维生素D3浓度超过了据报道对银屑病有效的范围，但我们未能在体内发现活性维生素D3对G0细胞动员有任何影响。