Kishimoto T, Okada K, Shimamoto F, Sato T, Ono T
Dept. of Clinical Investigation, Kure Kyosai Hospital.
Gan No Rinsho. 1988 Nov;34(14):1951-5.
Tumor tissues obtained from 5 cases of malignant mesothelioma and from 5 cases of primary adenocarcinoma of the lung have been studied on staining with the sialyl SSEA-1 antibody by the PAP method. Results in all cases of a malignant mesothelioma (both Epithelioid and Sarcomatous pattern) were absolutely negative. All cases of lung cancer, however, were positive, though in differing degrees. In evaluating a malignant mesothelioma, many reports have indicated that the negativity of CEA staining is useful in achieving the differential diagnosis from lung cancer. The sensitivity of the staining by sialyl SSEA-1 was found to be far better than that of CEA in examining either malignant mesothelioma or lung cancer. Thus, we found that not only CEA but also sialyl SSEA-1 antigen staining was useful for the diagnosing of a malignant mesothelioma.
对5例恶性间皮瘤和5例原发性肺腺癌的肿瘤组织进行了研究，采用过氧化物酶抗过氧化物酶（PAP）法用唾液酸化SSEA-1抗体染色。所有恶性间皮瘤病例（上皮样和肉瘤样模式）的结果均为绝对阴性。然而，所有肺癌病例均呈阳性，只是程度不同。在评估恶性间皮瘤时，许多报告表明癌胚抗原（CEA）染色阴性有助于与肺癌进行鉴别诊断。发现在检查恶性间皮瘤或肺癌时，唾液酸化SSEA-1染色的敏感性远优于CEA。因此，我们发现不仅CEA而且唾液酸化SSEA-1抗原染色对恶性间皮瘤的诊断都很有用。
