Alexis E. Cullen, MSc, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, UK; Helen L. Fisher, PhD, CPsychol, AFBPsS, MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK; Ruth E. Roberts, MSc, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, UK; Carmine M. Pariante, MD, MRCPsych, PhD, Section of Stress, Psychiatry and Immunology & Perinatal Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK; Kristin R. Laurens, PhD, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, UK, and Research Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, and Schizophrenia Research Institute, Sydney, Australia.
Br J Psychiatry. 2014;204:354-60. doi: 10.1192/bjp.bp.113.127001. Epub 2014 Mar 13.
Psychological stress is implicated in the development of schizophrenia, but little is known about experiences of stress among children at elevated risk for the disorder.
To examine stressor exposure and reactivity in children with different vulnerability profiles for schizophrenia: (a) children presenting multiple antecedents of schizophrenia (ASz group), (b) children with a family history of schizophrenia (FHx group) and (c) typically developing low-risk (TD) children.
Ninety-five children (ASz = 29; FHx = 19; ASz+FHx = 5; TD = 42), identified aged 9-12 years using a community-based screening procedure or as relatives of individuals with schizophrenia, completed questionnaires assessing environmental stressors and psychopathology at age 11-14 years.
Relative to their typically developing peers, children in the FHx and ASz groups were exposed to a greater number of negative life events and a higher frequency of daily stressors, respectively; and were more distressed by these experiences.
Stress exposure and reactivity may constitute useful targets of early intervention for psychosis.
心理压力与精神分裂症的发展有关，但对于处于该疾病高风险的儿童的压力体验知之甚少。
研究具有不同精神分裂症易感性特征的儿童的应激源暴露和反应性：(a)具有多种精神分裂症前期症状的儿童（ASz 组），(b)有精神分裂症家族史的儿童（FHx 组）和（c）发育正常的低风险（TD）儿童。
使用基于社区的筛选程序或作为精神分裂症个体亲属确定了 95 名儿童（ASz = 29；FHx = 19；ASz+FHx = 5；TD = 42），他们在 11-14 岁时完成了评估环境应激源和精神病理学的问卷。
与他们的正常发育同龄人相比，FHx 组和 ASz 组的儿童分别经历了更多的负面生活事件和更高频率的日常压力源，并且对这些经历感到更加痛苦。
应激源暴露和反应性可能是精神病早期干预的有用目标。
