National Cancer Institute, Division of Cancer Prevention, Biometry Research Group, 9609 Medical Center Drive, MSC 9789 Room 5E634, Rockville, MD 20892 and Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA.
Evol Med Public Health. 2014 Jan;2014(1):65-8. doi: 10.1093/emph/eou010. Epub 2014 Mar 12.
Drug-resistant bacteria are a huge and growing threat to public health. A solution exists in theory, but had not yet been put to a practical test. The accompanying paper by Ross-Gillespie et al., the theory is put to a test and performs successfully. As predicted, using a drug that targets bacteria's shared secreted 'public goods' molecules instead of cell components did not drive the bacterial evolution of drug resistance, and therefore retained its effectiveness. This result holds great promise for better drugs and vaccines against many infectious diseases, and also for better cancer therapies.
耐药细菌对公众健康构成巨大且日益严重的威胁。理论上存在一种解决方案,但尚未进行实际测试。罗斯-吉莱斯皮等人的相关论文对这一理论进行了测试并取得了成功。正如预测的那样,使用针对细菌共享分泌的“公共物品”分子而不是细胞成分的药物不会促使细菌产生耐药性,因此保持了其有效性。这一结果为开发针对许多传染病的更好药物和疫苗以及更好的癌症疗法带来了巨大的希望。