Küçük Mert, Altınkaya Sündüz Özlem, Nergiz Sümeyra, Sezer Selda Demircan, Yüksel Hasan, Bağlı İhsan, Yıldız Gülserap
Department of Gynecology and Obstetrics, Faculty of Medicine, Muğla Sıtkı Koçman University , Muğla , Turkey .
Gynecol Endocrinol. 2014 Jun;30(6):423-7. doi: 10.3109/09513590.2014.895981. Epub 2014 Mar 14.
The aim of this study was to evaluate serum concentrations of interleukin-6 (IL-6) in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS).
A total of 40 women with PCOS and 40 age-matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as IL-6 levels were evaluated in each subject.
Women with PCOS exhibited higher body mass index (BMI) and serum concentrations of IL-6 levels than controls (p < 0.05); however, levels of IL-6 were not significantly increased when compared with BMI-matched controls (p > 0.05). IL-6 levels were significantly correlated positively with BMI and triglyceride levels; however, negatively correlated with high-density lipoprotein levels.
The data of this study suggested that serum IL-6 levels were found to be higher in women with PCOS as compared to controls; however, IL-6 levels might be dependent on nutritional status but not on PCOS per se. Raised serum IL-6 levels may be related to BMI and serum lipid levels and may be a predictor for cardiometabolic risks.
本研究旨在评估多囊卵巢综合征（PCOS）患者和非PCOS患者血清白细胞介素-6（IL-6）浓度与激素及代谢指标的关系。
共有40例PCOS女性患者和40例年龄匹配的对照者纳入本研究。对每个受试者评估多毛症评分、激素及代谢指标以及IL-6水平。
PCOS女性患者的体重指数（BMI）和血清IL-6浓度高于对照组（p < 0.05）；然而，与BMI匹配的对照组相比，IL-6水平无显著升高（p > 0.05）。IL-6水平与BMI和甘油三酯水平呈显著正相关；然而，与高密度脂蛋白水平呈负相关。
本研究数据表明，与对照组相比，PCOS女性患者血清IL-6水平更高；然而，IL-6水平可能取决于营养状况而非PCOS本身。血清IL-6水平升高可能与BMI和血脂水平有关，可能是心血管代谢风险的一个预测指标。
