Brown R A, Tomlinson I W, Hill C R, Weiss J B, Phillips P, Kumar S
Ann Rheum Dis. 1983 Jun;42(3):301-7. doi: 10.1136/ard.42.3.301.
A low-molecular-weight freely dialysable angiogenesis factor has been isolated from 49 synovial fluids obtained from patients with various joint diseases. An analysis of disease type and incidence of freely dialysable angiogenesis activity showed that the osteoarthrotic group had a significantly higher incidence than all the other groups (p = 0.0332). Angiogenesis factor has also been detected in a bound form in the retentates of fluids which gave positive results for dialysable factor. The possibility that an imbalance between carrier-bound and free factor may have a causative role in disease is discussed.
已从49例患有各种关节疾病患者的滑液中分离出一种低分子量、可自由透析的血管生成因子。对疾病类型和可自由透析的血管生成活性发生率的分析表明，骨关节炎组的发生率明显高于所有其他组（p = 0.0332）。在对可透析因子检测呈阳性的液体截留物中也检测到了结合形式的血管生成因子。文中讨论了载体结合因子和游离因子之间的失衡可能在疾病中起致病作用的可能性。
